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ahmadieh--hamid
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Facilitation of Transscleral Drug Delivery
, M.Sc. Thesis Sharif University of Technology ; Abdekhodaie, Mohammad Jafar (Supervisor) ; Seifkordi, Aliakbar (Supervisor) ; Ahmadieh, Hamid (Co-Supervisor)
Abstract
In the present research the methods and challenges to ocular drug delivery have been investigated with more emphasis on ocular diseases that do not have any approved treatment. Periocular route is a promising alternative to the common routes of ocular drug delivery especially for treatment of posterior eye diseases. Based on barriers for efficient drug delivery to the eye, magnetic drug targeting revealed to be influential to eliminate some obstacles of this route which has not been worked before. It is hypothesized that the particles can pulled into the eye or will be trapped inside the sclera tissue or even if it is not happened, they can stay behind the sclera and magnetic force can...