Sharif Digital Repository

Background: cervical cancer is one of the most common malignancies in women worldwide and its management remains challenging and complex. As Cytochrome4Z1 (CYP4Z1) is overex-pressed in many tumours, its expression in cervical cancer is unknown. Therefore, the present study aimed to evaluate CYP4Z1 expression in cervical cancers. Methods: CYP4Z1 expression was immunohistochemically assessed in 100 cases of cervical cancers along with ten normal cervix tissues, and the enzyme’s relationship to several clinicopathological features and survival was explored. Results: CYP4Z1 was strongly expressed in 55% of cervical cancer patients. Normal cervix samples were negative for CYP4Z1 expression.... 

Purpose: Treatment of metastatic breast cancer patients is challenging and remains a major underlying cause of female mortality. Understanding molecular alterations in tumor development is critical to identify novel biomarkers and targets for cancer diagnosis and therapy. One of the aberrant cancer expressions gaining recent research interest is glypican-1. Several studies reported strong glypican-1 expression in various types of human cancers. However, none of these investigated glypican-1 expression in a large cohort of breast cancer histopathological subtypes. Patients and Methods: Immunohistochemistry was used to assess glypican-1 expression in 220 breast cancer patients and its relation... 

Background: The development of colon cancer has been described as a multistep process of carcinogenesis. Understanding molecular and cellular changes underlying this process is required to determine potential biomarkers and therapeutic targets in colon cancers. Several molecular entities, including glypicans, are implicated in cancer development. Among these is glypican-6, which is overexpressed in a limited number of cancers. This study aims to characterise the glypican-6 expression in different types of colon cancer. Methods: Immunohistochemistry was used to characterise glypican-6 expression in a panel of archived formalin-fixed, paraffin-embedded colon tissue types. These types included... 

Purpose: To evaluate the phytochemical profile of methanol extract of Ephedra foeminea and assess its anti-carcer effect on a large set of normal and cancerous cell lines Methods: Extraction of air-dried powder of aerial parts of E. foeminea was carried out with methanol. The bioactive compounds in the extract were determined using gas chromatography/mass spectrometry (GC-MS). The anti-cancer effect of the extract was determined by 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) assay against various types of normal and cancer cell lines. Serial concentrations of plant extract were used, ranging from 7.812 to1000 μg/mL. Doxorubicin (DOX) served as standard drug. The... 

Purpose: Colon cancer is a leading cause of mortality worldwide. It has a relatively poor prognosis; therefore, new therapies are needed. One of the tumour-related enzymes that has gained considerable interest is CYP4Z1. This enzyme has been expressed in many tumours and has been hypothesized as a potential biomarker or target for novel anticancer therapies. Patients and Methods: CYP4Z1 overexpression was immunohistochemically examined in a large panel of colon tissue types including normal, benign, primary and metastatic ones, and the enzyme’s relation to histopathological features and patient survival was evaluated. Results: A high CYP4Z1 expression was observed in benign, primary and... 

Purpose: Triple-negative breast cancer (TNBC) is characterized by high mortality rate, and its clinical management is difficult and complex. Therefore, there is a need for extensive efforts aimed at accelerating the discovery of novel therapies for TNBC. CYP4Z1 has been implicated in the development of breast cancer. The current study aimed at characterizing the expression of CYP4Z1 on TNBC. Materials and Methods: Using immunohistochemistry, CYP4Z1 expression was evaluated on 122 TNBC samples, four samples of breast cancers expressing ER, PR, and HER-2, and four samples of normal breast tissues. The association between the enzyme and various histopathological features and survival of... 

In poorly developed fractured rocks, the contribution of individual fracture on rock conductivity should be considered. However, due to the lack of data, a deterministic approach cannot be used. The conventional way to model discrete fractures is to use a Poisson process, with prescribed distribution, for fracture size and orientation. Recently, a stochastic approach, based on the idea that the elastic energy due to fractures follows a Boltzmann distribution, has been used to generate realizations of correlated fractures in two dimensions. The elastic energy function has been derived by applying the appropriate physical laws in an elastic medium. The resulting energy function has been used... 

Characterizing the electrical resistance of the formation rock is of great importance in, for example, interpreting the well log data, calculating the porosity, and water saturation for the formation rocks. The relation between the resistivity factor and porosity and also between the resistivity index and water saturation (Archie equation) in the formation rock uses the parameters, such as the cementation factor and saturation exponent. However, the direct application of Archie equation to carbonate rocks that are very heterogeneous and mostly oil-wet needs further investigation. In this experimental work, the effects of overburden pressure, temperature, and interfacial tension on the... 

Permeability reduction in porous media as a result of frail and tenuous fine particles migration would decrease the productivity index in the subterranean reservoirs. During reservoir stimulation by injecting fluids into the reservoir, as the salinity condition of the formation brine changes, fine particles initiate the triggering process. In this study, MgO-based nanofluid as a fines fixation agent was stably prepared based on the particle size distribution and characterized through transmission electron microscopy analysis. Afterward, several core flooding tests were performed using Berea sandstone cores to study the effect of nanofluid injection on fines fixation in the water shock... 

A mathematical time-dependent and isothermal model based on the grain model has been developed to simulate the kinetic and thermal behaviors of a porous iron oxide pellet undergoing chemical reactions with a mixture of hydrogen, carbon monoxide, carbon dioxide and water vapor. Its novelty consists in fact that it can deal with a multi-species reducing gas and oxide pellet. In spite of previous models in which the pure reductant was applied as reducing gas, this model can indicate an actual view of pellet reduction including the effects of reducing gas utility and reducing gas ratio. A finite volume fully implicit technique was applied for solving the governing equations. The model has been... 

The application of the renewable energy sources, especially solar energy, for thermal enhanced oil recovery methods as an economical and environmental valuable technique has received many attractions recently. Concentrated Solar Power systems are capable of producing substantial quantities of steam by means of focused sunlight as the heat source for steam generation. This paper aims to investigate viability of using this innovative technology in fractured reservoirs to generate steam instead of using conventional steam generators. A synthetic fractured reservoir with properties similar to those of giant carbonate oil reserves in the Middle East was designed by using commercial thermal... 

Although managing and controlling the inventories of perishable products is progressively becoming more important, they are often neglected in lot-sizing research and modeling. This paper studies a new multi-product multi-period dynamic lot sizing problem, where the inventories of products are assumed to be expired at a pre-specified date. For this purpose we assume a retailer that purchases products in large quantities (lot size) from manufacturers, and then sells smaller quantities (or single units) to the consumer. So, the order quantities can be merely an integer multiplier of that product batch size. The retailer also owns a capacitated warehouse. In order to make decisions on "how much... 

Inventory management of deteriorating items faces major challenges by uncertain demand, uncertain lead time, perishability, and high customer service level requirements. So, this issue is extremely important in many corporations today. The periodic up-to level policy for deteriorating products under stochastic demand and stochastic lead time is not paid enough attention up to now. In this paper we propose a new approach to study inventory up-to level policy of deteriorating products under normal distributed demand and lead time by considering service level requirements. To model deterioration process, a non-linear increasing holding cost function is considered. After developing the... 

It is very significant and practical to explore a triple hybrid nanofluid flow across the stuck zone of a stretching/ shrinking curved surface with impacts from stuck and Lorentz force factors. The combination (Ag-TiO2-Al2O3/blood) hybrid nanofluid is studied herein as it moves across a stagnation zone of a stretching/shrinking surface that curves under the impact of pressure and Lorentz force. Exact unsolvable nonlinear partial differential equations can be transformed into ordinary differential equations that can be solved numerically by similarity transformation. It was discovered that predominant heat transfers andmovement characteristics of quaternary hybrid nanofluids are dramatically... 

Rockfall is a significant hazard to sites that are located at the foot of rock slopes. In such sites, there is a notable need to evaluate the potential for rockfall, estimate the extent of areas at risk, and design retaining structures to reduce the risk of rockfall-induced. This paper presents a probabilistic framework for predicting the formation and progression of rockfalls and for evaluating the performance of retaining walls under rockfalls. To this end, first a probabilistic model for the rock projectile motion on a slope is presented. The model accounts for prevailing uncertainties, i.e., the trigger points, rock shape, projectile path, and slope material properties, which include... 

Communication networks with highly mobile users are emerging rapidly. Autonomous vehicular communication is an interesting example of such systems. High mobility speed causes drastic change in channel states, and consequently a doubly selective fading scenario is a proper model for such channels. In this paper, by considering this proper model, we introduce a multiuser system based on orthogonal signal division multiplexing in a cognitive radio scenario. Carrier interferometry codes are also utilized in this system. By designing the transmitter and receiver, the performance of such system is investigated. We show that this system works properly when users are moving rapidly, and moreover the... 

In this paper a new passive imaging method is introduced that is mainly suitable for Geo-locating LPI radars. The method uses two Electronic Support (ES) receivers located on a fast moving platform (e.g. an airplane or a satellite). The proposed method has a high processing gain which makes it absolutely suitable against very weak LPI signals. It is also capable in radar location finding against complex radars and complicated electromagnetic environment  

The unusual surface states of topological semimetals have attracted a lot of attention. Recently, we showed [Proc. Natl. Acad. Sci. USA 113, 8648 (2016)PNASA60027-842410.1073/pnas.1524787113] that for a Dirac semimetal (DSM) arising from band inversion, such as Na3Bi and Cd3As2, the expected double Fermi arcs on the surface are not topologically protected. Quite generally, the arcs deform into states similar to those on the surface of a strong topological insulator. Here we address two questions related to deformation and stability of surface states in DSMs. First, we discuss why certain perturbations, no matter how large, are unable to destroy the double Fermi arcs. We show that this is... 

In this paper the structure of Maximum Likelihood (ML) CFAR for lognormal clutter is derived assuming that some reference samples are censored to avoid destructive effect of interfering targets. It is shown that under some acceptable approximations we will achieve in a simple structure for this detector which is suitable for real time processing. The proposed detector is compared with non censored ML CFAR (i.e. logt CFAR) via simulation. It is shown that while the proposed detector is a little weaker than logt CFAR in homogeneous clutter, in non homogeneous clutter it outperforms the logt CFAR  

CFAR detector is an essential component in any radar system. This component ensures that the system may not be overloaded by false targets. In the past it was common to model the interfering signal (clutter) in a radar system with a Rayleigh distribution. But as a progress in the radar systems, nowadays the Rayleigh model is insufficient, therefore some other models such as Weibull and lognormal are proposed and CFAR detectors for these models are developed through the papers. But majority of these proposed CFAR detectors are derived for single pulse operation. When more than one pulse exists, it is proposed to use binary integrator to improve the performance. It is mentioned through...