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Fabrication of PLA/PEG/MWCNT electrospun nanofibrous scaffolds for anticancer drug delivery
, Article Journal of Applied Polymer Science ; Volume 132, Issue 3 , August , 2015 ; 00218995 (ISSN) ; Rad, L. R ; Irani, M ; Haririan, I ; Sharif University of Technology
John Wiley and Sons Inc
2015
Abstract
In the present study, polylactic acid (PLA)/polyethylene glycol (PEG)/multiwalled carbon nanotube (MWCNT) electrospun nanofibrous scaffolds were prepared via electrospinning process and their applications for the anticancer drug delivery system were investigated. A response surface methodology based on Box-Behnken design (BBD) was used to evaluate the effect of key parameters of electrospinning process including solution concentration, feeding rate, tip-collector distance (TCD) and applied voltage on the morphology of PLA/PEG/MWCNT nanofibrous scaffolds. In optimum conditions (concentration of 8.15%, feeding rate of 0.2 mL/h, voltage of 18.50 kV and TCD of 13.0 cm), the minimum experimental...
Modeling of high temperature rheological behavior of AZ61 Mg-alloy using inverse method and ANN
, Article Materials and Design ; Volume 29, Issue 9 , 2008 , Pages 1701-1706 ; 02641275 (ISSN) ; Sanjari, M ; Akbarzadeh, A ; Sharif University of Technology
2008
Abstract
Inverse method and artificial neural network were employed in modeling the rheological behavior of the AZ61 Mg alloy. The hot deformation behavior of these alloys was investigated by compression tests in the temperature range 250-350 °C and strain rate range 0.0005-0.1 s-1. Investigation of stress-strain curves and microstructure of the compression specimen illustrate occurrence of dynamic recrystallization. To determining parameters of two suggested constitutive equations global optimization technique, genetic algorithm, was used. The predicted results by inverse method and ANN depicted a good agreement with the experimental data even if the ANN results has shown the best predicted...
Controlled release of doxorubicin from electrospun PEO/chitosan/graphene oxide nanocomposite nanofibrous scaffolds
, Article Materials Science and Engineering C ; Volume 48 , March , 2015 , Pages 384-390 ; 09284931 (ISSN) ; Aboutalebi Anaraki, N ; Irani, M ; Roshanfekr Rad, L ; Shamshiri, S ; Sharif University of Technology
Elsevier Ltd
2015
Abstract
Polyethylene oxide (PEO)/chitosan (CS)/graphene oxide (GO) electrospun nanofibrous scaffolds were successfully developed via electrospinning process for controlled release of doxorubicin (DOX). The SEM analysis of nanofibrous scaffolds with different contents of GO (0.1, 0.2, 0.5 and 0.7 wt.%) indicated that the minimum diameter of nanofibers was found to be 85 nm for PEO/CS/GO 0.5% nanofibers. The π-π stacking interaction between DOX and GO with fine pores of nanofibrous scaffolds exhibited higher drug loading (98%) and controlled release of the DOX loaded PEO/CS/GO nanofibers. The results of DOX release from nanofibrous scaffolds at pH 5.3 and 7.4 indicated strong pH dependence. The...
The effect of stiffness on stress intensity factor for a crack in annular disc under constant central torque
, Article International Journal of Damage Mechanics ; Volume 19, Issue 8 , 2010 , Pages 1001-1015 ; 10567895 (ISSN) ; Gowhari Anaraki, A. R ; Hardy, S. J ; Sharif University of Technology
2010
Abstract
The finite element method has been used to predict the stress intensity factors for cracked annular discs under constant central torque. Linear elastic fracture mechanics finite element analyses have been performed and the results are demonstrated in the form of crack configuration factors. To this end, the extensive ranges of crack configuration factors have been employed while considering the effect of disc stiffness. Then, the finite element results are applied to develop equivalent prediction equations using a statistical multiple nonlinear regression model. The accuracy of this model is measured using a multiple coefficient of determination, R2, where 0 ≤R2 ≤1. This coefficient is found...
Analytical model of the electro-mechanical impedance response of frame structures with L-shaped beams
, Article Research in Nondestructive Evaluation ; Volume 31, Issue 3 , 2 January , 2020 , Pages 187-202 ; Hamzeloo, S. R ; Barzegar, M ; Pourkamali Anaraki, A ; Sharif University of Technology
Taylor and Francis Inc
2020
Abstract
The electro-mechanical impedance (EMI) method has been accepted as an effective technique for detecting damages in the Structural health monitoring (SHM). EMI at any point of the structure depends on material properties, geometry and boundary conditions that all appears in dynamic stiffness of the structure. In spite of the expensive experimental methods for measuring the mechanical impedance, or the cheaper one electromechanical impedance, of structures, various analytical methods could be substitutions for them. In this paper, an analytical method is developed to obtain the EMI response of L-shaped beams through calculating the dynamic stiffness of the structure. To verify the model, an...
Improved ring potential of QED at finite temperature and in the presence of weak and strong magnetic fields
, Article Physical Review D - Particles, Fields, Gravitation and Cosmology ; Volume 78, Issue 12 , 2008 ; 15507998 (ISSN) ; Sohrabi Anaraki, K ; Sharif University of Technology
2008
Abstract
Using the general structure of the vacuum polarization tensor Πμν(k0,k) in the infrared (IR) limit, k0→0, the ring contribution to the QED effective potential at finite temperature and the nonzero magnetic field is determined beyond the static limit, (k0→0, k→0). The resulting ring potential is then studied in weak and strong magnetic field limits. In the weak magnetic field limit, at high temperature and for α→0, the improved ring potential consists of a term proportional to T4α5/2, in addition to the expected T4α3/2 term arising from the static limit. Here, α is the fine structure constant. In the limit of the strong magnetic field, where QED dynamics is dominated by the lowest Landau...
Sifs for radial cracks in annular discs under internal and external shrinkage pressure and constant angular velocity
, Article ASME 2007 International Mechanical Engineering Congress and Exposition, IMECE 2007, 11 November 2007 through 15 November 2007 ; Volume 7 , 2007 , Pages 653-659 ; 0791843017 (ISBN) ; Gowhari Anaraki, A. R ; Hardy, S. J ; ASME ; Sharif University of Technology
American Society of Mechanical Engineers (ASME)
2007
Abstract
Finite element method has been implemented to predict stress intensity factors (SIFs) for radial cracks in annular discs under constant angular velocity. Effects of internal and external uniform pressure on the SIFs have also been considered. Linear elastic fracture mechanics finite element analyses have been performed and results are presented in the form of crack configuration factors for a wide range of components and crack geometry parameters. These parameters are chosen to be representative of typical practical situations. The extensive range of crack configuration factors obtained from the analyses is then used to develop equivalent prediction equations via a statistical multiple...
Synthesis and Investigation of Tribological Properties of Rubber-Based Friction Materials with low Friction Coefficient
, M.Sc. Thesis Sharif University of Technology ; Shojaei, Akbar (Supervisor)
Abstract
Nowadays, replacement of traditional cast iron shoes with composite brake blocks is a main project in railway systems. The main purpose of this replacement is noise reduction( for example by about 10dB for a 100km/h freight train). One of the main sources of noise emission is the rolling sound of the wheel on the rail. The rougher and more out-of-round wheel surface, the greater the noise produced. Cast iron brake shoes, still widely used on freight wagons, make the wheel surface much rougher than composite brake blocks due to the fusing of minute metal particles into the tread surface during braking. It is therefore necessary to replace the current cast iron brake shoe with a synthetic...
QED Ring Diagrams in Background Magnetic Field at Finite Temperature
, M.Sc. Thesis Sharif University of Technology ; Sadooghi, Neda (Supervisor)
Abstract
Using the general structure of the vacuum polarization tensor П_μν (k_0→0,k) in the infrared (IR) limit, k_0→0 , the ring contribution to the QED effective potential at finite temperature and the nonzero magnetic field is determined beyond the static limit, (k_0→0,k→0). The resulting ring potential is then studied in weak and strong magnetic field limits. In the weak magnetic field limit and at high temperature the improved ring potential consists of a term proportional to T^4 α^(5/2), in addition to the expected term T^4 α^(3/2) arising from the static limit. In the limit of the strong magnetic field, where QED dynamics is dominated by the lowest Landau level, the ring potential includes a...
STAT3 as a newly emerging target in colorectal cancer therapy: tumorigenesis, therapy response, and pharmacological/nanoplatform strategies
, Article Environmental Research ; Volume 233 , 2023 ; 00139351 (ISSN) ; Abbaszadeh, S ; Rashidi, M ; Amini, N ; Talebi Anaraki, K ; Motahhary, M ; Khalilipouya, E ; Harif Nashtifani, A ; Shafiei, S ; Ramezani Farani, M ; Nabavi, N ; Salimimoghadam, S ; Aref, A. R ; Raesi, R ; Taheriazam, A ; Entezari, M ; Zha, W ; Sharif University of Technology
Academic Press Inc
2023
Abstract
Colorectal cancer (CRC) ranks as the third most aggressive tumor globally, and it can be categorized into two forms: colitis-mediated CRC and sporadic CRC. The therapeutic approaches for CRC encompass surgical intervention, chemotherapy, and radiotherapy. However, even with the implementation of these techniques, the 5-year survival rate for metastatic CRC remains at a mere 12–14%. In the realm of CRC treatment, gene therapy has emerged as a novel therapeutic approach. Among the crucial molecular pathways that govern tumorigenesis, STAT3 plays a significant role. This pathway is subject to regulation by cytokines and growth factors. Once translocated into the nucleus, STAT3 influences the...
Synthesis and Characterization of Nano Hydroxyapatite/Acrylated Polyurethane Nanocomposites
, M.Sc. Thesis Sharif University of Technology ; Shojaei, Akbar (Supervisor) ; Abdekhodai, Mohammad Jafar (Supervisor)
Abstract
In the present study, the acrylated polyurethane/nanohydroxyapatite (APU/n-HAp) nanocomposites were fabricated for use in bone tissue regeneration. The APU was synthesized based on poly(ε-caprolactone) diol (PCL), aliphatic 1,6- hexamethylene diisocyanate (HDI) and hydroxyethyl methyl acrylate (HEMA). The effect of HAp nanoparticles on the physicochemical properties of APU was evaluated. The APU/n-HAp nanocomposites were characterized using X-ray diffraction (XRD), dynamic mechanical thermal analyses (DMTA), scanning electron microscopy (SEM) and mechanical tests including tensile strength and elongation at break. The increase in physical properties achieved by incorporation of n-HAp...
Processing and properties of nanofibrous bacterial cellulose-containing polymer composites: a review of recent advances for biomedical applications
, Article Polymer Reviews ; Volume 60, Issue 1 , 2020 , Pages 144-170 ; Mahmoodi, A ; Mahmoudi, N ; Zandi, N ; Simchi, A ; Sharif University of Technology
Taylor and Francis Inc
2020
Abstract
Bacterial cellulose (BC) is an extracellular natural polymer produced by many microorganisms and its properties could be tailored via specific fabrication methods and culture conditions. There is a growing interest in BC derived materials due to the main features of BC such as porous fibrous structure, high crystallinity, impressive physico-mechanical properties, and high water content. However, pristine BC lacks some features, limiting its practical use in varied applications. Thus, fabrication of BC composites has been attempted to overcome these constraints. This review article overviews most recent advance in the development of BC composites and their potential in biomedicine including...
A meta user interface for interaction with mixed reality environments
, Article 2015 IEEE International Symposium on Haptic, Audio and Visual Environments and Games, HAVE 2015 - Proceedings, 11 October 2015 ; October , 2015 , Page(s): 1 - 6 ; 9781467391757 (ISBN) ; Shirehjini, A. A. N ; Daraei, S ; Khojasteh, N ; Shirmohammadi, S ; Sharif University of Technology
Institute of Electrical and Electronics Engineers Inc
2015
Abstract
The aim of this paper is the design and development of a novel user interface to interact with a meta system. Our focus is rather on interacting with Ambient Intelligence as a whole, which would for example enable users to influence the overall behaviors and attributes of dynamic device compositions. We call such interfaces Meta User Interfaces. The design details of a proposed user interface as well as a cognitive walkthrough evaluation are presented in this paper
Effect of graphene oxide nanosheets on the physico-mechanical properties of chitosan/bacterial cellulose nanofibrous composites
, Article Composites Part A: Applied Science and Manufacturing ; Volume 85 , 2016 , Pages 113-122 ; 1359835X (ISSN) ; Eslahi, N ; Mahmoudi, N ; Simchi, A ; Sharif University of Technology
Elsevier Ltd
2016
Abstract
In this work, novel chitosan/bacterial cellulose (CS/BC) nanofibrous composites reinforced with graphene oxide (GO) nanosheets are introduced. As cell attachment and permeability of nanofibrous membranes highly depend on their fiber diameter, the working window for successful electrospinning to attain sound nanofibrous composites with a minimum fiber diameter was determined by using the response surface methodology. It is shown that the addition of GO nanosheets to CS/BC significantly reduces the average size of the polymeric fibers. Their mechanical properties are also influenced and can be tailored by the concentration of GO. Fourier transform infrared spectroscopy reveals hydrogen bonding...
Effect of RGO/Zn:XCd1- xS crystalline phase on solar photoactivation processes
, Article RSC Advances ; Volume 6, Issue 52 , 2016 , Pages 46282-46290 ; 20462069 (ISSN) ; Tedadi, N ; Banazadeh, A ; Naseri, N ; Sharif University of Technology
Royal Society of Chemistry
2016
Abstract
A series of reduced graphene oxide/ZnxCd1-xS (RGO/ZnxCd1-xS) nanocomposites (0 < x < 1) with different ratios of Zn/Cd were synthesized via a facile hydrothermal route under optimized experimental conditions and were carefully characterized by various techniques. Because very little is known about the morphology, specific surface area, and crystal phase effects of RGO/ZnxCd1-xS crystals on their photoresponsivity, field-emission scanning electron microscopy (FE-SEM), BET surface area analysis and X-ray diffraction (XRD) data were studied to investigate their effects on photoactivity. Based on the results, a crystal phase transition from a cubic phase in RGO/Zn0.9Cd0.1S to a hexagonal...
Mechanically stable superhydrophobic nanostructured aluminum mesh with reduced water surface friction
, Article Nanotechnology ; Volume 32, Issue 19 , 2021 ; 09574484 (ISSN) ; Afzali, N ; Taghvaei, N ; Moosavi, A ; Sharif University of Technology
IOP Publishing Ltd
2021
Abstract
Superhydrophobic surfaces demonstrate significant characteristics which make them suitable for a wide variety of applications. In this study, we propose a facile, one-step, and cost-effective anodizing scheme using aluminum nitrate/stearic acid mixture solution to create a superhydrophobic surface on an aluminum mesh. The surface outperforms the surface anodized by the widely used oxalic acid solution in terms of superhydrophobicity and water-surface friction behavior. The proposed surface reduced the friction by 11% on average respective to the surface prepared by oxalic acid. The durability of the introduced superhydrophobic surface has also been investigated. The proposed surface retained...
Promoting the optimal maintenance schedule of generating facilities in open systems
, Article International Conference on Power System Technology, PowerCon 2002, 13 October 2002 through 17 October 2002 ; Volume 1 , 2002 , Pages 641-645 ; 0780374592 (ISBN); 9780780374591 (ISBN) ; Ranjbar, A. M ; Sadati, N ; Sharif University of Technology
Institute of Electrical and Electronics Engineers Inc
2002
Abstract
This paper presents a dynamic programming methodology for finding the optimum preventive maintenance schedule of generating units of a GENCO in open power systems. The objective function for the GENCO is to sell electricity as much as possible, according to the market price forecast. Various constraints such as generation capacity, duration of maintenance and maintenance crew are taken into account. In a case study, introducing a GENCO with six generating units, and implementing dynamic programming, we obtain the optimal maintenance schedule over the planning period. © 2002 IEEE
Oxygen permeation and oxidative coupling of methane in membrane reactor: A new facile synthesis method for selective perovskite catalyst
, Article Journal of Molecular Catalysis A: Chemical ; Volume 286, Issue 1-2 , 2008 , Pages 79-86 ; 13811169 (ISSN) ; Nazari, K ; Safekordi, A. A ; Seyed Matin, N ; Ahmadi, R ; Esmaeili, N ; Tofigh, A ; Sharif University of Technology
2008
Abstract
A dense membrane of La0.6Sr0.4Co0.8Fe0.2O3- δ (LSCF) perovskite was prepared by a new chelating agent, ethylene diamine N,N,N′,N′-tetra N-acetyl diamine (EDTNAD). As a potent ligand, EDTNAD provided a facile one-step method to form complexes of the four metal ions, simultaneously. The oxygen permeation flux through the pure perovskite LSCF dense membrane was measured over temperature range of 1073-1223 K, thickness of 0.7-1.0 mm and oxygen partial pressure of 0.1-1.0 bar. Oxidative coupling of methane (OCM) reaction using LSCF disk in the atmospheric membrane reactor and over the temperature range of 1073-1173 K showed a C2 selectivity of 100% and C2 yield of 5.01% at 1153 K. Furthermore,...
Synchronization of hidden hyperchaotic attractors in fractional-order complex-valued systems with application to secure communications
, Article 2021 IEEE Conference of Russian Young Researchers in Electrical and Electronic Engineering, ElConRus 2021, 26 January 2021 through 28 January 2021 ; 2021 , Pages 62-67 ; 9780738142753 (ISBN) ; Kuznetsov, N. V ; Mokaev, T. N ; Tavazoei, M. S ; Sharif University of Technology
Institute of Electrical and Electronics Engineers Inc
2021
Abstract
Synchronization of fractional-order hyperchaotic complex systems is an interesting phenomenon since it has several applications in applied sciences. Based on the complexity of hyperchaotic dynamical systems and unpredictability of hidden attractors, which may exist in their phase spaces and could be beneficial in secure communications, a scheme to derive the analytical formula of the control functions is stated to study active control synchronization. Further comparison of this analytical formula with numerical experiments yields an interesting agreement. A novel fractional-order complex Sprott system is proposed to study this kind of synchronization and its dynamics. A secure communication...
Effects of boundary layer control method on hydrodynamic characteristics and tip vortex creation of a hydrofoil
, Article Polish Maritime Research ; Volume 24, Issue 2 , 2017 , Pages 27-39 ; 12332585 (ISSN) ; Tanha, A ; Kourabbasloo, N. N ; Tavakoli, S ; Sharif University of Technology
De Gruyter Open Ltd
2017
Abstract
There is currently a significant focus on using boundary layer control (BLC) approach for controlling the flow around bodies, especially the foil sections. In marine engineering this is done with the hope of increasing the lift - to - drag ratio and efficiency of the hydrofoils. In this paper, effects of the method on hydrodynamic characteristics and tip vortex formation of a hydrofoil are studied. Steady water injection at the tip of the hydrofoil is simulated in different conditions by using ANSYS-CFX commercial software. Validity of the proposed simulations is verified by comparing the obtained results against available experimental data. Effects of the injection on the lift, drag, and...