Sharif Digital Repository

The preparation of microcapsules containing perphenazine by solvent evaporation using ethyl cellulose is described. The microparticles are formed after solvent evaporation and polymer precipitation. The drug was dissolved in a polymer solution and emulsified into an aqueous phase to form microcapsules. To study the effects on particle size, encapsulation efficiency and morphology, three different molecular weights of ethyl cellulose (Mw=47000, 71000 and 99000) were used. Covalent bonding of drugs to polymers via hydrolytically or enzymatically cleavable covalent bond was achieved for sustained drug delivery. The release rate of perphenazine from these systems was investigated  

We conducted a study to explore the potential utility of the GATE Monte Carlo (MC) code as an independent tool for dose calculation. We established a unified framework for dose calculation in pencil beam scanning (PBS) proton therapy (PT). Using GATE, we modeled the SIEMENS IONTRIS active scanned-based PT system. To verify the model, we compared depth dose profiles obtained from the MC simulation with experimental date. Additionally, we utilized the TG-119 clinical test case from AAPM to assess the accuracy of treatment planning and delivery using proton beams. The results of the MC simulation demonstrated strong agreement with measurements, revealing a 2.3% in mean point-To-point, maximum... 

Surgical simulators have been widely used in training and evaluation of physicians and surgeons. Virtual reality augmented with haptic technology has made it feasible to develop more realistic surgical simulators. In this context, we set out to design and develop a brain surgery bipolar electrocautery simulator using haptic technology. A 3D model of brain tissue was generated based on a brain craniotomy image. Bipolar forceps were also modeled to visually assimilate real forceps. An experiment was developed to assess the learning process of the participants. In this experiment, the volunteers were asked to cauterize a large blood vessel in the brain while minimizing the damage done to the... 

Analytic Hierarchy Process (AHP) is one of the most popular approaches in the area of multiple attribute decision making (MADM). However, it is not practical any more if input information are fuzzy. In this paper, we propose a new method for fuzzy AHP which is especially useful to make decisions for multiple attribute problems. The method is developed by applying preference ratio concept which makes it practical since it assigns crisp weights and crisp scores to different alternatives. Two algorithms are proposed in this paper: The first one defines crisp and normalized weight by pairwise comparison with fuzzy data while the second one calculates fuzzy consistency ratio. The proposed method... 

This paper investigates the metallurgical and mechanical response of 2304 duplex stainless steel-as an interesting candidate for automotive body-in-white applications-to resistance spot welding. The results showed the high cooling rate associated with the resistance spot welding process suppressed the postsolidification ferrite-austenite transformation leading to improper ferrite-austenite phase balance with a reduced volume fraction of austenite and consequent precipitation of chromium-rich nitrides. The effects of welding current, as the key parameter determining the weld heat input, on the austenite volume fraction and precipitation are discussed. The minimum fusion zone hardness... 

Synthetic CT (sCT) generation from MR images is yet one of the major challenges in the context of MR-guided radiation planning as well as quantitative PET/MR imaging. Deep convolutional neural networks have recently gained special interest in large range of medical imaging applications including segmentation and image synthesis. In this study, a novel deep convolutional neural network (DCNN) model is presented for synthetic CT generation from single T1-weighted MR image. The proposed method has the merit of highly accelerated convergence rate suitable for applications where the number of training da-taset is limited while highly robust model is required. This algorithm exploits a Visual... 

Purpose: Despite the proven utility of multiparametric magnetic resonance imaging (MRI) in radiation therapy, MRI-guided radiation treatment planning is limited by the fact that MRI does not directly provide the electron density map required for absorbed dose calculation. In this work, a new deep convolutional neural network model with efficient learning capability, suitable for applications where the number of training subjects is limited, is proposed to generate accurate synthetic computed tomography (sCT) images from MRI. Methods: This efficient convolutional neural network (eCNN) is built upon a combination of the SegNet architecture (a 13-layer encoder-decoder structure similar to the... 

The simulation and experimental results obtained from stretching test of a commercial sheet of AA1200 aluminum alloy were compared and evaluated. Uniaxial tensile tests were carried out to obtain the required input parameters for simulation. Finite element analysis of the forming process was carried out using Abaqus/Explicit by considering von Mises and Hill-1948 yield criteria. Simulation results including punch force and strain distribution were compared and validated with the experimental results. The results reveal that using anisotropic yield criteria for simulation has a better match in both cases with the experiments  

Introduction: The purpose of this work was to assess the feasibility of acquisition time reduction in MPI-SPECT imaging using deep leering techniques through two main approaches, namely reduction of the acquisition time per projection and reduction of the number of angular projections. Methods: SPECT imaging was performed using a fixed 90° angle dedicated dual-head cardiac SPECT camera. This study included a prospective cohort of 363 patients with various clinical indications (normal, ischemia, and infarct) referred for MPI-SPECT. For each patient, 32 projections for 20 seconds per projection were acquired using a step and shoot protocol from the right anterior oblique to the left posterior... 

Introduction: The purpose of this work was to assess the feasibility of acquisition time reduction in MPI-SPECT imaging using deep leering techniques through two main approaches, namely reduction of the acquisition time per projection and reduction of the number of angular projections. Methods: SPECT imaging was performed using a fixed 90° angle dedicated dual-head cardiac SPECT camera. This study included a prospective cohort of 363 patients with various clinical indications (normal, ischemia, and infarct) referred for MPI-SPECT. For each patient, 32 projections for 20 seconds per projection were acquired using a step and shoot protocol from the right anterior oblique to the left posterior... 

Redundancy technique is considered as a way to enhance the reliability and availability of a system. This paper models availability of a repairable system with multiple subsystems in which the involved components follow the load sharing strategy. In redundancy allocation problems, the redundancy level is just considered, whereas, in this paper, the number of repair facility (repairman) is added to the decision variables. The goal is to find the optimal number of repairmen and redundant components in each subsystem for optimization of availability subject to weight, cost and volume constraints. The main contribution of this study is to present a straightforward model for availability... 

The two-dimensional two-fluid model (TFM) incorporating the kinetic theory of granular flow was used to simulate the hydrodynamic behavior of gas bubbles in tapered fluidized beds. Because numerous previous works conducted were mainly focused on the hydrodynamic behavior of the beds such as pressure drop, minimum fluidization velocity, and bed expansion ratio, it is required to investigate one of the most significant parameters in tapered fluidized beds (i.e., gas bubble diameter and rising velocity). The experimental data obtained in our laboratory were compared with the simulation results, and good agreement was found. Effects of the superficial gas velocity, apex angle, particle size,... 

Elevated levels of nitrate (NO3) in groundwater systems pose a serious risk to human populations and natural ecosystems. As part of an effort to remediate NO3 contamination in irrigated stream-aquifer systems, this study elucidates agricultural and environmental parameters and processes that govern NO3 fate and transport at the regional (500 km2), local (50 km2), and field scales (<1 km2). Specifically, the revised Morris sensitivity analysis method was applied to a finite-difference nitrogen cycling and reactive transport model of a regional-scale study site in the lower Arkansas River valley in southeastern Colorado. The method was used to rank the influence of anthropogenic activities and...