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RSM based engineering of the critical gelation temperature in magneto-thermally responsive nanocarriers
, Article European Polymer Journal ; Volume 120 , 2019 ; 00143057 (ISSN) ; Bagheri, R ; Madaah Hosseini, H. R ; Bagherzadeh, E ; Sharif University of Technology
Elsevier Ltd
2019
Abstract
The multistep release of therapeutic agents in the theranostic particulate systems has remained as a challenge in smart drug delivery. In this study, superparamagnetic nanoparticles of Fe3O4 were coated with a blend of F127/F68 grades of pluronic in order to adjust the lower critical solution temperature (LCST) and consequently engineering of the release temperature. Pluronic as a biocompatible thermo-sensitive polymer is frequently used as a self-emulsifying drug delivery system. Magnetite nanoparticles with double layer coating of oleic acid and pluronic F127 have been reported as an on-demand smart carrier for hydrophobic drugs. LCST was examined using differential scanning calorimetry...