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bahrami-samani--ali
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Mathematical Modeling of 188Re-PSMA in Rats and its Human Absorbed dose Estimation
, M.Sc. Thesis Sharif University of Technology ; Vosoughi, Naser (Supervisor) ; Yousefnia, Hassan (Supervisor) ; Bahrami Samani, Ali (Co-Supervisor)
Abstract
Prostate cancer is the second most common cancer in men and the fourth leading cause of death in the world. In this study, the 188Re-HYNIC-PSMA radiolabeled compound was produced as a compound for use in the treatment of prostate cancer and its metastases under optimal labeling conditions and its radiochemical purity was obtained above 98% using RTLC and HPLC chromatographic methods. This compound is stable at room temperature and in human blood serum for at least 48 hours after preparation. The biological distribution of this compound was investigated in each rat tissue and the amount of injected activity per unit mass of each tissue (%ID/g) was determined. The bio-distribution of 188...