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Nano mesoporous silica for cancer treatment: ROS-responsive and redox-responsive carriers
, Article Journal of Drug Delivery Science and Technology ; Volume 57 , 2020 ; Abdekhodaie, M. J ; Behroozi, F ; Mehrvar, M ; Sharif University of Technology
Editions de Sante
2020
Abstract
Reactive oxygen species ROS and redox agents are two features of cancer medium, which could be used through responsive drug delivery systems for cancer treatment. Furthermore, mesoporous silica nanoparticles (MSNs) have special characteristics to use them in ROS-responsive and redox-responsive carriers. To shed light on this issue, we propose two drug delivery systems: 1) responsive to hydrogen peroxide (a ROS component) and 2) responsive to dithiothreitol (a redox agent). The proposed carriers are composed of 4 parts: MSNs, responsive agent (selenocystine for ROS-responsive and dithiodipropionic for the redox-responsive carrier), hyaluronic acid as the coating and targeting agent, and the...