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Investigation of a Novel Microfluidic Device for Label-Free Ferrohydrodynamic Cell Separation on a Rotating Disk
, Article IEEE Transactions on Biomedical Engineering ; Volume 67, Issue 2 , 2020 , Pages 372-378 ; Besanjideh, M ; Sharif University of Technology
IEEE Computer Society
2020
Abstract
Negative magnetophoresis is a novel and attractive method for continuous microparticle sorting inside a magnetic medium. In this method, diamagnetic particles are sorted based on their sizes using magnetic buoyancy force and without any labeling process. Although this method provides some attractive features, such as low-cost fabrication and ease of operation, there are some obstacles that adversely affect its performance, especially for biological applications. Most types of magnetic media, such as ferrofluids, are not biocompatible, and the time-consuming process of sample preparation can be threatening to the viability of the cells within the sample. Furthermore, in this method, both the...
Cancer cell enrichment on a centrifugal microfluidic platform using hydrodynamic and magnetophoretic techniques
, Article Scientific Reports ; Volume 11, Issue 1 , 2021 ; 20452322 (ISSN) ; Naghdloo, A ; Besanjideh, M ; Sharif University of Technology
Nature Research
2021
Abstract
Isolation of rare cancer cells is one of the important and valuable stages of cancer research. Regarding the rarity of cancer cells in blood samples, it is important to invent an efficient separation device for cell enrichment. In this study, two centrifugal microfluidic devices were designed and fabricated for the isolation of rare cancer cells. The first design (passive plan) employs a contraction–expansion array (CEA) microchannel which is connected to a bifurcation region. This device is able to isolate the target cells through inertial effects and bifurcation law. The second design (hybrid plan) also utilizes a CEA microchannel, but instead of using the bifurcation region, it is...
Droplet-based microfluidics in biomedical applications
, Article Biofabrication ; Volume 14, Issue 2 , 2022 ; 17585082 (ISSN) ; Besanjideh, M ; Nasiri, R ; Shamloo, A ; Nasrollahi, F ; De Barros, N. R ; Davoodi, E ; Erdem, A ; Mahmoodi, M ; Hosseini, V ; Montazerian, H ; Jahangiry, J ; Darabi, M.A ; Haghniaz, R ; Dokmeci, M.R ; Annabi, N ; Ahadian, S ; Khademhosseini, A ; Sharif University of Technology
IOP Publishing Ltd
2022
Abstract
Droplet-based microfluidic systems have been employed to manipulate discrete fluid volumes with immiscible phases. Creating the fluid droplets at microscale has led to a paradigm shift in mixing, sorting, encapsulation, sensing, and designing high throughput devices for biomedical applications. Droplet microfluidics has opened many opportunities in microparticle synthesis, molecular detection, diagnostics, drug delivery, and cell biology. In the present review, we first introduce standard methods for droplet generation (i.e. passive and active methods) and discuss the latest examples of emulsification and particle synthesis approaches enabled by microfluidic platforms. Then, the applications...