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Nanotechnology-Abetted Astaxanthin Formulations in Multimodel Therapeutic and Biomedical Applications
, Article Journal of Medicinal Chemistry ; 2021 ; 00222623 (ISSN) ; Bigham, A ; Sadeghi, S ; Dehdashti, S. M ; Rabiee, N ; Abedivash, A ; Bagherzadeh, M ; Nasseri, B ; Karimi Maleh, H ; Sharifi, E ; Varma, R. S ; Makvandi, P ; Sharif University of Technology
American Chemical Society
2021
Abstract
Astaxanthin (AXT) is one of the most important fat-soluble carotenoids that have abundant and diverse therapeutic applications namely in liver disease, cardiovascular disease, cancer treatment, protection of the nervous system, protection of the skin and eyes against UV radiation, and boosting the immune system. However, due to its intrinsic reactivity, it is chemically unstable, and therefore, the design and production processes for this compound need to be precisely formulated. Nanoencapsulation is widely applied to protect AXT against degradation during digestion and storage, thus improving its physicochemical properties and therapeutic effects. Nanocarriers are delivery systems with many...
Multifunctional tetracycline-loaded silica-coated core-shell magnetic nanoparticles: antibacterial, antibiofilm, and cytotoxic activities
, Article ACS Applied Bio Materials ; Volume 5, Issue 4 , 2022 , Pages 1731-1743 ; 25766422 (ISSN) ; Eshrati Yeganeh, F ; Yousefi, M ; Baniyaghoob, S ; Farasati Far, B ; Akbarzadeh, I ; Bigham, A ; Ashrafizadeh, M ; Rabiee, N ; Makvandi, P ; Saeb, M. R ; Sharif University of Technology
American Chemical Society
2022
Abstract
In the current study, the physicochemical and biological properties of tetracycline-loaded core-shell nanoparticles (Tet/Ni0.5Co0.5Fe2O4/SiO2 and Tet/CoFe2O4/SiO2) were investigated. The antibacterial activity of nanoparticles alone and in combination with tetracycline was investigated against a number of Gram-positive and Gram-negative bacteria for determining minimum inhibitory concentration (MIC) values. The MIC of Tet/Ni0.5Co0.5Fe2O4/SiO2 nanoparticles turned out to be significantly higher than that of Tet/CoFe2O4/SiO2 nanoparticles. Furthermore, Tet/Ni0.5Co0.5Fe2O4/SiO2 nanoparticles exhibited potent antibiofilm activity against pathogenic bacteria compared to Tet/CoFe2O4/SiO2...
Nanotechnology-Abetted astaxanthin formulations in multimodel therapeutic and biomedical applications
, Article Journal of Medicinal Chemistry ; Volume 65, Issue 1 , 2022 , Pages 2-36 ; 00222623 (ISSN) ; Bigham, A ; Sadeghi, S ; Dehdashti, S. M ; Rabiee, N ; Abedivash, A ; Bagherzadeh, M ; Nasseri, B ; Karimi Maleh, H ; Sharifi, E ; Varma, R. S ; Makvandi, P ; Sharif University of Technology
American Chemical Society
2022
Abstract
Astaxanthin (AXT) is one of the most important fat-soluble carotenoids that have abundant and diverse therapeutic applications namely in liver disease, cardiovascular disease, cancer treatment, protection of the nervous system, protection of the skin and eyes against UV radiation, and boosting the immune system. However, due to its intrinsic reactivity, it is chemically unstable, and therefore, the design and production processes for this compound need to be precisely formulated. Nanoencapsulation is widely applied to protect AXT against degradation during digestion and storage, thus improving its physicochemical properties and therapeutic effects. Nanocarriers are delivery systems with many...