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Development of a polyvinyl alcohol/sodium alginate hydrogel-based scaffold incorporating bFGF-encapsulated microspheres for accelerated wound healing
, Article Scientific Reports ; Volume 10, Issue 1 , 2020 ; Shamloo, A ; Dorri Nokoorani, Y ; Sharif University of Technology
Nature Research
2020
Abstract
In the present study, a hybrid microsphere/hydrogel system, consisting of polyvinyl alcohol (PVA)/sodium alginate (SA) hydrogel incorporating PCL microspheres is introduced as a skin scaffold to accelerate wound healing. The hydrogel substrate was developed using the freeze-thawing method, and the proportion of the involved polymers in its structure was optimized based on the in-vitro assessments. The bFGF-encapsulated PCL microspheres were also fabricated utilizing the double-emulsion solvent evaporation technique. The achieved freeze-dried hybrid system was then characterized by in-vitro and in-vivo experiments. The results obtained from the optimization of the hydrogel showed that...
Explicit finite element modeling of wear within the patellofemoral joint in total knee replacement
, Article 26th National and 4th International Iranian Conference on Biomedical Engineering, ICBME 2019, 27 November 2019 through 28 November 2019 ; 2019 , Pages 208-212 ; 9781728156637 (ISBN) ; Dorri Nokoorani, Y ; Barati, K ; Farahmand, F ; Sharif University of Technology
Institute of Electrical and Electronics Engineers Inc
2019
Abstract
Total knee replacement (TKR) surgery is one of the most successful and cost-effective procedures for treating knee injuries performed in orthopedics. However, the knee replacement revision surgery will probably be required after some years. Wear at the contact area between femoral metal component and the polyethylene inserts in TKR is recognized as one of the foremost causes of prosthesis failure and necessity of revision surgery. In the present study, focusing on the patellofemoral joint (PFJ), the wear at the contact area between the patellar and femoral components has been simulated employing the explicit finite element modeling. In this regard, common types of patellar component surface...
Fluidic barriers in droplet-based centrifugal microfluidics: Generation of multiple emulsions and microspheres
, Article Sensors and Actuators, B: Chemical ; Volume 311 , May , 2020 ; Madou, M. J ; Dorri Nokoorani, Y ; Shamloo, A ; Martinez Chapa, S. O ; Sharif University of Technology
Elsevier B. V
2020
Abstract
Droplet generation is very important in biochemical processes such as cell encapsulation, digital PCR (Polymerase Chain Reaction), and drug delivery. In the present paper, a density-based method called “fluidic barrier” is introduced to produce multiple emulsions on a centrifugal microfluidic platform or Lab-on-a-CD (LOCD). We show that the density and the viscosity of the fluids involved are important parameters for predicting the characteristics of the droplets generated with this method. Moreover, we broadened this concept by using the fluidic barriers to separate reactive chemicals. As a proof of concept, alginate and CaCl2 solutions are separated by an oil barrier to control the...