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    A colorimetric assay for d-Penicillamine in urine and plasma samples based on the aggregation of gold nanoparticles

    , Article Journal of the Iranian Chemical Society ; Vol. 11, issue. 5 , Dec , 2014 , p. 1249-1255 Hormozi-Nezhad, M. R ; Azargun, M ; Fahimi-Kashani, N ; Sharif University of Technology
    We report herein the development of a highly sensitive colorimetric method for detection of d-Penicillamine using citrate-capped gold nanoparticles (AuNPs). This assay relies upon the distance-dependent of gold nanoparticles surface plasmon resonance band of gold nanoparticles. By replacing the thiol-containing chelator drug, d-Penicillamine, with citrate on the gold nanoparticles surface, a new peak appearing at a longer wavelength intensifies and shifts further to the red from the original peak position due to aggregation of gold nanoparticles which depends on ionic strength, gold nanoparticles and d-Penicillamine concentration. During this process, the plasmon band at 521 nm decreases... 

    Aggregation-based colorimetric sensor for determination of prothioconazole fungicide using colloidal silver nanoparticles (AgNPs)

    , Article Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy ; Volume 187 , 2017 , Pages 143-148 ; 13861425 (ISSN) Ivrigh, Z. J. N ; Fahimi Kashani, N ; Hormozi Nezhad, M. R ; Sharif University of Technology
    There is a growing interest in developing high-performance sensors monitoring fungicides, due to their broadly usage and their adverse effects on humans and wildlife. In the present study, a colorimetric probe has been proposed for detection of prothioconazole based on aggregation of unmodified silver nanoparticles (AgNPs). Under optimized condition, linear relationships between the concentration of prothioconazole and the absorbance ratio of A500/A395 were found over the range of 0.01 μg·mL− 1 to 0.4 μg·mL− 1 with quantification limit as low as 1.7 ng·mL− 1. Furthermore, AgNPs color change from yellow to pink-orange in presence of prothioconazole, indicates highly sensitive naked-eye... 

    Mining the potential of label-free biosensors for in vitro antipsychotic drug screening

    , Article Biosensors ; Volume 8, Issue 1 , 2018 ; 20796374 (ISSN) Kilic, T ; Soler, M ; Fahimi Kashani, N ; Altug, H ; Carrara, S ; Sharif University of Technology
    MDPI AG  2018
    The pharmaceutical industry is facing enormous challenges due to high drug attribution rates. For the past decades, novel methods have been developed for safety and efficacy testing, as well as for improving early development stages. In vitro screening methods for drug-receptor binding are considered to be good alternatives for decreasing costs in the identification of drug candidates. However, these methods require lengthy and troublesome labeling steps. Biosensors hold great promise due to the fact that label-free detection schemes can be designed in an easy and low-cost manner. In this paper, for the first time in the literature, we aimed to compare the potential of label-free optical and... 

    A ratiometric fluorescence nanoprobe using CdTe QDs for fast detection of carbaryl insecticide in apple

    , Article Talanta ; Volume 221 , 2021 ; 00399140 (ISSN) Shahdost fard, F ; Fahimi Kashani, N ; Hormozi nezhad, M. R ; Sharif University of Technology
    Elsevier B.V  2021
    In this study, a novel, simple and sensitive ratiometric fluorescence method is presented for the detection of very low quantities of the carbaryl in Iranian apple using cadmium telluride quantum dots (CdTe QDs) nanoprobe. The principle of the proposed strategy relies on the rapid hydrolysis of the carbaryl under an alkaline condition and production of the 1-naphthol with a blue emission at 470 nm. Besides, using the CdTe QDs with a yellow emission at 580 nm, as a reference, improves the visual tracking of carbaryl through changes in color tonality. The herein described methodology is applied for enzyme-free visual detection of carbaryl with satisfactory results in the presence of other... 

    Development of a colorimetric sensor array based on monometallic and bimetallic nanoparticles for discrimination of triazole fungicides

    , Article Analytical and Bioanalytical Chemistry ; April , 2021 ; 16182642 (ISSN) Kalantari, K ; Fahimi Kashani, N ; Hormozi Nezhad, M. R ; Sharif University of Technology
    Springer Science and Business Media Deutschland GmbH  2021
    Due to the widespread use of pesticides and their harmful effects on humans and wildlife, monitoring their residual amounts in crops is critically essential but still challenging regarding the development of high-throughput approaches. Herein, a colorimetric sensor array has been proposed for discrimination and identification of triazole fungicides using monometallic and bimetallic silver and gold nanoparticles. Aggregation-induced behavior of AgNPs, AuNPs, and Au-AgNPs in the presence of four triazole fungicides produced a fingerprint response pattern for each analyte. Innovative changes to the metal composition of nanoparticles leads to the production of entirely distinct response patterns... 

    Nanoparticle-based optical sensor arrays

    , Article Nanoscale ; Volume 9, Issue 43 , 2017 , Pages 16546-16563 ; 20403364 (ISSN) Bigdeli, A ; Ghasemi, F ; Golmohammadi, H ; Abbasi Moayed, S ; Nejad, M. A. F ; Fahimi-Kashani, N ; Jafarinejad, S ; Shahrajabian, M ; Hormozi-Nezhad, M. R ; Sharif University of Technology
    As in many other methods that have integrated nanoparticles (NPs), the chemical nose/tongue strategy has also progressed greatly since the entrance of NPs into this field. The fascinating tunable physicochemical properties of NPs have made them powerful candidates for array-based sensing platforms and have enabled the development of real-time, sensitive and portable systems that are able to target complex mixtures of analytes. In particular, the unique optical properties of NPs have a key role in providing promising array-based sensing approaches. This review will describe the main aspects and processes of most common NP-based optical sensor arrays. The fundamental steps in the design of a... 

    Ratiometric fluorescent nanoprobes for visual detection: Design principles and recent advances - A review

    , Article Analytica Chimica Acta ; Volume 1079 , 2019 , Pages 30-58 ; 00032670 (ISSN) Bigdeli, A ; Ghasemi, F ; Abbasi Moayed, S ; Shahrajabian, M ; Fahimi Kashani, N ; Jafarinejad, S ; Farahmand Nejad, M. A ; Hormozi Nezhad, M. R ; Sharif University of Technology
    Elsevier B.V  2019
    Signal generation techniques for visual detection of analytes have received a great deal of attention in various sensing fields. These approaches are considered to be advantageous when instrumentation cannot be employed, such as for on-site assays, point-of-care tests, and he althcare diagnostics in resource-constrained areas. Amongst various visual detection approaches explored for non-invasive quantitative measurements, ratiometric fluorescence sensing has received particular attention as a potential method to overcome the limitations of intensity-based probes. This technique relies on changes in the intensity of two or more emission bands (induced by an analyte), resulting in an effective... 

    Optical nanoprobes for chiral discrimination

    , Article Analyst ; Volume 145, Issue 20 , 2020 , Pages 6416-6434 Bigdeli, A ; Ghasemi, F ; Fahimi Kashani, N ; Abbasi Moayed, S ; Orouji, A ; Jafar Nezhad Ivrigh, Z ; Shahdost Fard, F ; Hormozi Nezhad, M. R ; Sharif University of Technology
    Royal Society of Chemistry  2020
    Chiral discrimination has always been a hot topic in chemical, food and pharmaceutical industries, especially when dealing with chiral drugs. Enantiomeric recognition not only leads to better understanding of the mechanism of molecular recognition in biological systems, but may further assist in developing useful molecular devices in biochemical and pharmaceutical studies. By emerging nanotechnology and exploiting nanomaterials in sensing applications, a great deal of attention has been given to the design of optical nanoprobes that are able to discriminate enantiomers of chiral analytes. This review explains how engineering nanoparticles (NPs) with desired physicochemical properties allows...