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    Anodic behavior of clioquinol at a glassy carbon electrode

    , Article Bioelectrochemistry ; Volume 80, Issue 2 , 2011 , Pages 175-181 ; 15675394 (ISSN) Ghalkhani, M ; Fernandes, I. P. G ; Oliveira, S. C. B ; Shahrokhian, S ; Oliveira-Brett, A. M ; Sharif University of Technology
    Clioquinol is an antifungal, antiprotozoal and an Alzheimer's disease drug with cytotoxic activity toward human cancer cells. The electrochemical behavior of clioquinol and its oxidation product was studied using cyclic, differential pulse and square-wave voltammetry over a wide pH range on a glassy carbon electrode. The results revealed that the oxidation of clioquinol is an irreversible pH-dependent process that proceeds with the transfer of one electron and one proton in an adsorption-controlled mechanism and results in the formation of a main oxidation product, which adsorbs very strongly on the glassy carbon surface. The charge transfer coefficient was calculated as 0.64. The adsorbed... 

    Electrochemical Redox Behaviour of Temozolomide Using a Glassy Carbon Electrode

    , Article Electroanalysis ; Volume 22, Issue 22 , September , 2010 , Pages 2633-2640 ; 10400397 (ISSN) Ghalkhani, M ; Fernandes, I. P. G ; Oliveira , S. C. B ; Shahrokhian, S ; Oliveira Brett, A. M ; Sharif University of Technology
    The electrochemical behaviour of temozolomide on a glassy carbon electrode has been investigated. The reduction of temozolomide is an irreversible process, pH dependent, and the mechanism involves the addition of one electron and one proton to C5 to form an anion radical, causing the irreversible breakdown of the tetrazinone ring. The oxidation mechanism of temozolomide is an irreversible, adsorption-controlled process, pH dependent up to value close to the pKa and occurs in two consecutive charge transfer reactions, with the formation of the hydroxylated product. The electroanalytical determination of TMZ led to a detection limit of 1.1 μM