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hasanzadeh--zabihollah
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Design and Fabrication of Scaffold Composed of Acellular Cartilage Matrix and Chitosan
, M.Sc. Thesis Sharif University of Technology ; Mashayekhan, Shohreh (Supervisor) ; Hasanzadeh, Zabihollah (Supervisor)
Abstract
Cartilage is an avascular tissue, having limited ability to repair itself. Since the methods for treatment of cartilage defects have been not effective, in recent years, new therapies based on tissue engineering are considered.This paper reports on the development of porous microcarriers composed of acellular matrix of cartilage and natural polymer chitosan. Microcarriers were prepared by electrospray method. Results of mechanical tests, SEM imaging, water uptake behaviour, biodegradation test, and MTT assay demonstrated that the microcarriers composed of 2% (wt) chitosan and 1% (wt) ECM has the best potential for growth and proliferation of primary chondrocyte cells. These results...
Fabrication of in Situ Forming Bioadhesive Hydrogel for Cartilage Tissue Engineering
, M.Sc. Thesis Sharif University of Technology ; Mashayekhan, Shohreh (Supervisor) ; Hasanzadeh, Zabihollah (Supervisor)
Abstract
In recent years, many efforts have been made in tissue engineering and new methods for the treatment of cartilage damage, with an emphasis on their non-invasive and less aggressive nature. Meanwhile, injectable and in situ forming hydrogels have been considered as a less invasive nature. On the other hand, lack of enough mechanical properties in these hydrogels is one of their main problem. In this study, gelatin and alginate was used to fabricate hydrogel as interpenetrating network (IPN) hydrogel and silica nano particles were also used to increase mechanical properties in the fabricating of hydrogels. Gelatin is also combined with dopamine in order to induce bio adhesive properties of...