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hassanzadeh--zabihollah
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Fabrication of in Situ Forming Hydrogels Composed of Acellular Cartilage Matrix with Improved Mechanical Properties for Recovery of Local Damages in Articular Cartilage
, M.Sc. Thesis Sharif University of Technology ; Mashayekhan, Shohreh (Supervisor) ; Hassanzadeh, Zabihollah (Co-Supervisor)
Abstract
Since cartilage has limited self-regeneration, in-situ forming hydrogels can act as an ideal scaffold for cartilage tissue engineering to fill the defect gap due to their ability to homogeneously encapsulate the desired cells, efficient mass transfer and minimally invasive characteristics. In this project, an injectable hydrogel with improved structure by adding silk fibroin (SF) nanofibers and better biochemical properties by employing the cartilage extracellular matrix (ECM) was fabricated. The in-situ forming hydrogel is consisted of different concentrations of ionic crosslinked alginate incorporated with different concentrations of SF nanofibers and 1% w/v enzymatically crosslinked...