Sharif Digital Repository

Breast Cancer is considered one of the most common cancers among Iranian women. Every year, seven thousands women start suffering from this disease. Since 70 percent of this patients live over 5 years, after this disease starts, there are 70 thousands women who are suffering from the cancer. The average age of getting the disease in Iran is 5 years lower than that of the global level. Studies show that compound containing Chromene and Carboxamides are appropriate candidates for preventing breast cancer. One of the most important fields of researches in Chemistry and Bio-Chemistry is QSAR which is used to relate the structure of molecules to their activities. In this study, molecular... 

This PhD dissertation presents the chemometric techniques as a tool to obtain maximum information from the chemical and biological systems. In this regards, two objectives have been followed. The first objective was to apply the design of experiment methods for approaching the most reliable data. In this section, the main concepts and applications of experimental design approaches to optimize the common analytical chemistry techniques are reviewed. The critical steps and tools for screening including Plackett-Burman, full factorial- and fractional factorial designs and response surface methodology such as central composite, Box-Behnken and Doehlert designs are discussed. Descriptions of... 

In recent years, chromatographic techniques as one of the most important analytical techniques have been greatly developed from instrumentation and data volume point of views. On the other side, multivariate curve resolution (MCR) techniques as a branch of chemometrics have potential for the analysis of multivariate and huge data sets. In addition, MCR methods have been developed very fast in these years and their potential have been shown in the analysis of different types of chemical data. Thus, combination of sophisticated chromatographic techniques (e.g. gas chromatography-mass spectrometry (GC-MS) or comprehensive two-dimensional gas chromatography (GC×GC)) with MCR techniques can be... 

Zinc oxide(ZnO) nanoparticles have been used in a wide-ranging of applications such as transparent UV protection, medical treatments, light emitting diodes, sensors and photovoltaic cells. Many applications of ZnO nanoparticles could be improved by changing the particle size, shape and morphology. In order to take advantage of the unique size dependent properties observed for ZnO anoparticles, knowledge of how particle growth can be controlled is required. As an alternative to transmittance electron microscopy (TEM), which is already used in the study of size and monodispersity of ZnO nanoparticles during synthesis, we proposed a simple spectrophotometric method coupled with chemometric...