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The prominent role of fully-controlled surface co-modification procedure using titanium nanotubes and silk fibroin nanofibers in the performance enhancement of Ti6Al4V implants
, Article Surface and Coatings Technology ; Volume 412 , 2021 ; 02578972 (ISSN) ; Sadrnezhaad, K ; Johari, N ; Sharif University of Technology
Elsevier B.V
2021
Abstract
Modification of orthopedic implant surfaces through advanced nanoscale coating methods has made a major breakthrough in maximizing implantation success. Adjustable drug release and biocompatibility are among the most momentous features since they can significantly prevent the implantation failure. In this study, the potential of silk fibroin (SF) nanofibers fabricated via electrospinning, along with titanium oxide nanotube arrays (TNTs) formed through anodization, were exploited to produce a cyto-biocompatible, well-controlled drug delivery system. Highly-ordered TNTs were formed in an organic electrolyte solution within 2 h at the voltage of 60 V under temperature controlling (16 °C)....