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kazemi--akhtarolmolouk
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Design and Synthesis of a Novel Nanomaterial as a Carrier of a Hydrophobe drug in an Inclusion Complex based on Cychlodextrin
, M.Sc. Thesis Sharif University of Technology ; Vossoughi, Manouchehr (Supervisor) ; Kazemi, Akhtarolmolouk (Supervisor)
Abstract
Paclitaxel is used as a drug against breast and ovarian cancers. Although paclitaxel has high biologic activity, it has very pour solubility in water like some other drugs. Since drugs should be solved in water to be absorbed by the body, for absorb enhancement, we should use carriers which includes both polar and non polar sites. eta-Cyclodextrin which has this feature is capable for producing inclusion complex in its hydrophobic pores with non polar materials. In this project by adding polymeric polyacrylamide branches on beta-Cyclodextrin, polymeric nano structure has been developed to enhance water solubility in comparison with pure beta-Cyclodextrin. Study on producing polymeric nano...
Optimization of Lipase Immobilization
, M.Sc. Thesis Sharif University of Technology ; Aalemzadeh, Iran (Supervisor) ; Kazemi, Akhtarolmolouk (Supervisor)
Abstract
In this study, Pseudomonas aeruginosa BBRC-10036 was used for lipase production. The organism secreted the enzyme extracellulary. First of all, effect of initial pH of the culture broth on lipase activity was studied in order to determine the optimum condition for lipase production. After production, this enzyme must be separated from culture and after that the enzyme must be purified for using in analysis and industry. Different methods are used for purification of the enzyme. In this research, first precipitation was used and then this lipase has been purified by Ion exchange Chromatography leading to 2.33- fold purification and 11.47% recovery. In precipitation by acetone, maximum...