Sharif Digital Repository

Conformational diseases, constituting a large number of diseases, have been connected with protein misfolding, leading to aggregation known as amyloid fibrils. Mainly due to the lack of detailed molecular mechanisms, there has not been an effective drug to combat amyloid-associated diseases. Recently, a small organic pyridazine-based molecule (RS-0406) has shown significant reductions in amyloid fibrils in both in vitro and in vivo animal studies. However, no information on molecular details of inhibition for the small molecule has been reported. In this work, we have decided to explore structure-activity relationship of pyridazine-based compounds to investigate structural parameters for... 

People usually get involved in multiple social networks to enjoy new services or to fulfill their needs. Many new social networks try to attract users of other existing networks to increase the number of their users. Once a user (called source user) of a social network (called source network) joins a new social network (called target network), a new inter-network link (called anchor link) is formed between the source and target networks. In this paper, we concentrated on predicting the formation of such anchor links between heterogeneous social networks. Unlike conventional link prediction problems in which the formation of a link between two existing users within a single network is... 

Community detection in social networks has become a popular topic of research during the last decade. There exist a variety of algorithms for modularizing the network graph into different communities. However, they mostly assume that partial or complete information of the network graphs are available that is not feasible in many cases. In this article, we focus on detecting communities by exploiting their diffusion information. To this end, we utilize the Conditional Random Fields (CRF) to discover the community structures. The proposed method, community diffusion (CoDi), does not require any prior knowledge about the network structure or specific properties of communities. Furthermore, in... 

We report the effect of gold nanoparticles on the sensitivity and selectivity of SnO2-based sensors for detection of CO in the presence of methane and C3H8, a model compound representing liquid petroleum gas (LPG). 1.0 wt% Au/SnO2 powder was prepared by a co-precipitation method. The powder formed was washed, dried at 150 °C, and calcined at 300 °C for 3 h. The BET surface area of SnO2 and Au/SnO2 was measured to be 210 and 110 m2/g, corresponding to 4 and 7.5 nm loose spherical particles, respectively. Responses of the Au/SnO2 and SnO2 sensors to 40-1000 ppm CO, 0.2-1.0% C3H8 and 1.0-3.0% CH4 were studied at 170-300 °C in an automated gas sensing system. In this temperature range, the... 

Monitoring large-scale networks is a critical yet challenging task. Enormous number of nodes and links, limited power, and lack of direct access to the entire network are the most important difficulties. In applications such as network routing, where all nodes need to monitor the status of the entire network, the situation is even worse. In this letter, a collaborative model in which nodes pick up information from measurements generated by other nodes is proposed. Using this model, for the first time, an upper bound is derived for the number of measurements that each node must generate, such that the expected number of measurements observed by each node is sufficient to provide a global view... 

This paper introduces a novel framework for modeling temporal events with complex longitudinal dependency that are generated by dependent sources. This framework takes advantage of multidimensional point processes for modeling time of events. The intensity function of the proposed process is a mixture of intensities, and its complexity grows with the complexity of temporal patterns of data. Moreover, it utilizes a hierarchical dependent nonparametric approach to model marks of events. These capabilities allow the proposed model to adapt its temporal and topical complexity according to the complexity of data, which makes it a suitable candidate for real world scenarios. An online inference... 

Poisson factorization is a probabilistic model of users and items for recommendation systems, where the so-called implicit consumer data is modeled by a factorized Poisson distribution. There are many variants of Poisson factorization methods who show state-of-the-art performance on real-world recommendation tasks. However, most of them do not explicitly take into account the temporal behavior and the recurrent activities of users which is essential to recommend the right item to the right user at the right time. In this paper, we introduce Recurrent Poisson Factorization (RPF) framework that generalizes the classical PF methods by utilizing a Poisson process for modeling the implicit... 

Poisson Factorization (PF) is the gold standard framework for recommendation systems with implicit feedback whose variants show state-of-the-art performance on real-world recommendation tasks. However, most of the previous work do not explicitly take into account the temporal behavior of users which is essential to recommend the right item to the right user at the right time. In this paper, we introduce a Recurrent Poisson Factorization (RPF) framework that generalizes the classical PF methods by utilizing a Poisson process for modeling the implicit feedback. RPF treats time as a natural constituent of the model, and takes important factors for recommendation into consideration to provide a... 

Poisson Factorization (PF) is the gold standard framework for recommendation systems with implicit feedback whose variants show state-of-the-art performance on real-world recommendation tasks. However, they do not explicitly take into account the temporal behavior of users which is essential to recommend the right item to the right user at the right time. In this paper, we introduce Recurrent Poisson Factorization (RPF) framework that generalizes the classical PF methods by utilizing a Poisson process for modeling the implicit feedback. RPF treats time as a natural constituent of the model, and takes important factors for recommendation into consideration to provide a rich family of... 

In real world social networks, there are multiple cascades which are rarely independent. They usually compete or cooperate with each other. Motivated by the reinforcement theory in sociology we leverage the fact that adoption of a user to any behavior is modeled by the aggregation of behaviors of its neighbors. We use a multidimensional marked Hawkes process to model users product adoption and consequently spread of cascades in social networks. The resulting inference problem is proved to be convex and is solved in parallel by using the barrier method. The advantage of the proposed model is twofold; it models correlated cascades and also learns the latent diffusion network. Experimental...