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Polysaccharide-based nanocomposites for biomedical applications: a critical review
, Article Nanoscale Horizons ; Volume 7, Issue 10 , 2022 , Pages 1136-1160 ; 20556756 (ISSN) ; Shokrani, A ; Sajadi, S. M ; Khodadadi Yazdi, M ; Seidi, F ; Jouyandeh, M ; Zarrintaj, P ; Kar, S ; Kim, S. J ; Kuang, T ; Rabiee, N ; Hejna, A ; Saeb, M. R ; Ramakrishna, S ; Sharif University of Technology
Royal Society of Chemistry
2022
Abstract
Polysaccharides (PSA) have taken specific position among biomaterials for advanced applications in medicine. Nevertheless, poor mechanical properties are known as the main drawback of PSA, which highlights the need for PSA modification. Nanocomposites PSA (NPSA) are a class of biomaterials widely used as biomedical platforms, but despite their importance and worldwide use, they have not been reviewed. Herein, we critically reviewed the application of NPSA by categorizing them into generic and advanced application realms. First, the application of NPSA as drug and gene delivery systems, along with their role in the field as an antibacterial platform and hemostasis agent is discussed. Then,...