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    Designing and modeling a centrifugal microfluidic device to separate target blood cells

    , Article Journal of Micromechanics and Microengineering ; Volume 26, Issue 3 , 2016 ; 09601317 (ISSN) Shamloo, A ; Selahi, Aa ; Madadelahi, M ; Sharif University of Technology
    Institute of Physics Publishing  2016
    The objective of this study is to design a novel and efficient portable lab-on-a-CD (LOCD) microfluidic device for separation of specific cells (target cells) using magnetic beads. In this study the results are shown for neutrophils as target cells. However, other kinds of target cells can be separated in a similar approach. The designed microfluidics can be utilized as a point of care system for neutrophil detection. This microfluidic system employs centrifugal and magnetic forces for separation. After model validation by the experimental data in the literature (that may be used as a design tool for developing centrifugo-magnetophoretic devices), two models are presented for separation of... 

    Numerical simulation of centrifugal serpentine micromixers and analyzing mixing quality parameters

    , Article Chemical Engineering and Processing: Process Intensification ; Volume 104 , 2016 , Pages 243-252 ; 02552701 (ISSN) Shamloo, A ; Madadelahi, M ; Akbari, A ; Sharif University of Technology
    Elsevier, B.V  2016
    Centrifugal microfluidics or the Lab on a CD (LOCD) has developed vast applications in biomedical researches and analyses. Fluid mixing is an application of the LOCD. In this paper, multiple centrifugal micromixers were simulated. Various parameters were originally presumed to have an effect on mixing performance. These parameters include inlet angle, angular velocity, cross-sectional profile, perpendicular length ratio and the number of channels in series. They were each analyzed through simulations. It was gathered that the inlet angle does not significantly affect the mixing quality. Increasing angular velocity steadily increases mixing quality for all geometries. The vertical triangular... 

    Three-dimensional numerical simulation of a novel electroosmotic micromixer

    , Article Chemical Engineering and Processing: Process Intensification ; Volume 119 , 2017 , Pages 25-33 ; 02552701 (ISSN) Shamloo, A ; Madadelahi, M ; Abdorahimzadeh, S ; Sharif University of Technology
    Elsevier B.V  2017
    Lab-on-a-chip (LOC) systems have been widely used in chemical and medical analyses. In this study, a novel T-shaped electroosmotic micromixer was simulated and the effects of different parameters on the mixing process were examined. These parameters include; inlet angle, number of conducting hurdles, arrangements of the hurdles, geometry of hurdles and chambers, aspect ratios of the channel cross-sectional profile, hurdle radius, and depth. It was found that the inlet angle has a direct influence on mixing index (σ). The effect of various number of hurdles (one, two, three and four hurdles) and their orientations was investigated. Simulations revealed that using two conducting hurdles is the... 

    Secondary flows, mixing, and chemical reaction analysis of droplet-based flow inside serpentine microchannels with different cross sections

    , Article Langmuir ; Volume 37, Issue 17 , 2021 , Pages 5118-5130 ; 07437463 (ISSN) Ghazimirsaeed, E ; Madadelahi, M ; Dizani, M ; Shamloo, A ; Sharif University of Technology
    American Chemical Society  2021
    Chemical bioreactions are an important aspect of many recent microfluidic devices, and their applications in biomedical science have been growing worldwide. Droplet-based microreactors are among the attractive types of unit operations, which utilize droplets for enhancement in both mixing and chemical reactions. In the present study, a finite-volume-method (FVM) numerical investigation is conducted based on the volume-of-fluid (VOF) applying for the droplet-based flows. This multiphase computational modeling is used for the study of the chemical reaction and mixing phenomenon inside a serpentine microchannel and explores the effects of the aspect ratio (i.e., AR = height/width) of... 

    Volume and concentration dosing in picolitres using a two-channel microfluidic AFM cantilever

    , Article Nanoscale ; Volume 12, Issue 18 , 2020 , Pages 10292-10305 Verlinden, E. J ; Madadelahi, M ; Sarajlic, E ; Shamloo, A ; Engel, A. H ; Staufer, U ; Ghatkesar, M. K ; Sharif University of Technology
    NLM (Medline)  2020
    We introduce a two-channel microfluidic atomic force microscopy (AFM) cantilever that combines the nanomechanical sensing functionality of an AFM cantilever with the ability to manipulate fluids of picolitres or smaller volumes through nanoscale apertures near the cantilever tip. Each channel is connected to a separate fluid reservoir, which can be independently controlled by pressure. Various systematic experiments with fluorescent liquids were done by either injecting the liquids from the on-chip reservoir or aspirating directly through the nanoscale apertures at the tip. A flow rate analysis of volume dosing, aspiration and concentration dosing inside the liquid medium was performed. To...