Sharif Digital Repository

Superparamagnetic Iron Oxide NPs (SPIONs) because of their multi-task capabilities (e.g. magnetic labeling, cell isolation, hyperthermiaand controlled drug release) have been recognized as one of the most promising NPs for theranosis applications.When NPs come in contact with a biological medium, the surfaces of them are covered by biomolecules (e.g., proteins, natural organic materials, and enzymes). Therefore, what a biological entity, such as cells, tissues, and organs, sees when interacting with NPs is different original pristine surface of the NPs and actually is hard protein corona. Shape of NPs has a great impact on proteins adsorb onto its surface and consequently on the way that... 

One of the most promising strategies for fighting cancer is the drug delivery process using synthetic nanoparticles. Once in biological milieu, the nanoparticle surfaces get covered with a layer of biomolecules called the “Protein Corona”. The protein corona formation changes the nanoparticles interaction with the human body dictating a new fate for them. The protein corona composition is not only dependent on the nanoparticle itself, but also it is affected by the health condition of patients as recently discovered through the experimental studies. Here, the effect of disease on the protein corona formation is discussed through the molecular dynamics simulations. A multiscale simulation...