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In vitro study: synthesis and evaluation of Fe3O4/CQD magnetic/fluorescent nanocomposites for targeted drug delivery, MRI, and cancer cell labeling applications
, Article Langmuir ; Volume 38, Issue 12 , 2022 , Pages 3804-3816 ; 07437463 (ISSN) ; Ahmadi, R ; Heydari, M ; Rahimipour, M. R ; Molaei, M. J ; Unsworth, L ; Sharif University of Technology
American Chemical Society
2022
Abstract
In the present study, first, Fe3O4nanoparticles were functionalized using glutaric acid and then composited with CQDs. Doxorubicin (DOX) drug was loaded to evaluate the performance of the nanocomposite for targeted drug delivery applications. The XRD pattern confirmed the presence of characteristic peaks of CQDs and Fe3O4. In the FTIR spectrum, the presence of carboxyl functional groups on Fe3O4/CQDs was observed; DOX (positive charge) is loaded onto Fe3O4/CQDs (negative charge) by electrostatic absorption. FESEM and AFM images showed that the particle sizes of Fe3O4and CQDs were 23-75 and 1-3 nm, respectively. The hysteresis curves showed superparamagnetic properties for Fe3O4and Fe3O4/CQDs...