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Investigation of a protein complex network
, Article European Physical Journal B ; Volume 41, Issue 1 , 2004 , Pages 113-121 ; 14346028 (ISSN) ; Ramezanpour, A ; Karimipour, V ; Sharif University of Technology
2004
Abstract
The budding yeast Saccharomyces cerevisiae is the first eukaryote whose genome has been completely sequenced. It is also the first eukaryotic cell whose proteome (the set of all proteins) and interactome (the network of all mutual interactions between proteins) has been analyzed. In this paper we study the structure of the yeast protein complex network in which weighted edges between complexes represent the number of shared proteins. It is found that the network of protein complexes is a small world network with scale free behavior for many of its distributions. However we find that there are no strong correlations between the weights and degrees of neighboring complexes. To reveal...