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    Comparison between Lagrangian and Eulerian approaches in predicting motion of micron-sized particles in laminar flows

    , Article Atmospheric Environment ; Vol. 89, issue , 2014 , Pages 199-206 ; ISSN: 13522310 Saidi, M. S ; Rismanian, M ; Monjezi, M ; Zendehbad, M ; Fatehiboroujeni, S ; Sharif University of Technology
    Modeling the behavior of suspended particles in gaseous phase is important for diverse reasons; e.g. aerosol is usually the main subject of CFD simulations in clean rooms. Additionally, to determine the rate and sites of deposition of particles suspended in inhaled air, the motion of the particles should be predicted in lung airways. Meanwhile there are two basically different approaches to simulate the behavior of particles suspension, Lagrangian and Eulerian approaches. This study compares the results of these two approaches on simulating the same problem. An in-house particle tracking code was developed to simulate the motion of particles with Lagrangian approach. In order to simulate the... 

    An alternative mechanism for the formation of high density lipoprotein in peripheral tissue

    , Article Scientia Iranica ; Volume 23, Issue 2 , 2016 , Pages 600-608 ; 10263098 (ISSN) Damirchi, B ; Saidi, M. S ; Rismanian, M ; Firoozabadi, B ; Amininasab, M ; Sharif University of Technology
    Sharif University of Technology  2016
    High Density Lipoprotein (HDL) is a lipid-protein complex responsible for transporting cholesterol and triglyceride molecules, as these compounds are unable to dissolve in aqueous environments such as a bloodstream. Among the most well-known possible structures, the belt-like structure is the most common shape proposed for this vital bimolecular complex. In this structure, the protein scaffold encompasses the lipid bilayer and a planar circular structure is formed. Several HDL simulations with embedded components in the lipid section were performed. Here, we applied a series of molecular dynamic simulations using the MARTINI coarse grain force field to investigate an HDL model, with pores of... 

    Organ-tumor-on-a-chip for chemosensitivity assay: A critical review

    , Article Micromachines ; Volume 7, Issue 8 , 2016 ; 2072666X (ISSN) Kashaninejad, N ; Nikmaneshi, M. R ; Moghadas, H ; Kiyoumarsi Oskouei, A ; Rismanian, M ; Barisam, M ; Saidi, M. S ; Firoozabadi, B ; Sharif University of Technology
    MDPI AG  2016
    With a mortality rate over 580,000 per year, cancer is still one of the leading causes of death worldwide. However, the emerging field of microfluidics can potentially shed light on this puzzling disease. Unique characteristics of microfluidic chips (also known as micro-total analysis system) make them excellent candidates for biological applications. The ex vivo approach of tumor-on-a-chip is becoming an indispensable part of personalized medicine and can replace in vivo animal testing as well as conventional in vitro methods. In tumor-on-a-chip, the complex three-dimensional (3D) nature of malignant tumor is co-cultured on a microfluidic chip and high throughput screening tools to evaluate...