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    Smart mesoporous silica nanoparticles for controlled-release drug delivery

    , Article Nanotechnology Reviews ; Volume 5, Issue 2 , 2016 , Pages 195-207 ; 21919089 (ISSN) Karimi, M ; Mirshekari, H ; Aliakbari, M ; Sahandi Zangabad, P ; Hamblin, M. R ; Sharif University of Technology
    Walter de Gruyter GmbH  2016
    Abstract
    Stimuli-responsive controlled-release nanocarriers are promising vehicles for delivery of bioactive molecules that can minimize side effects and maximize efficiency. The release of the drug occurs when the nanocarrier is triggered by an internal or external stimulus. Mesoporous silica nanoparticles (MSN) can have drugs and bioactive cargos loaded into the high-capacity pores, and their release can be triggered by activation of a variety of stimulus-responsive molecular "gatekeepers" or "nanovalves." In this mini-review, we discuss the basic concepts of MSN in targeted drug-release systems and cover different stimulus-responsive gatekeepers. Internal stimuli include redox, enzymes, and pH,... 

    Albumin nanostructures as advanced drug delivery systems

    , Article Expert Opinion on Drug Delivery ; Volume 13, Issue 11 , 2016 , Pages 1609-1623 ; 17425247 (ISSN) Karimi, M ; Bahrami, S ; Baghaee Ravari, S ; Sahandi Zangabad, P ; Mirshekari, H ; Bozorgomid, M ; Sharif University of Technology
    Taylor and Francis Ltd  2016
    Abstract
    Introduction: One of the biggest impacts that the nanotechnology has made on medicine and biology, has been in the area of drug delivery systems (DDSs). Many drugs suffer from serious problems concerning insolubility, instability in biological environments, poor uptake into cells and tissues, sub-optimal selectivity for targets and unwanted side effects. Nanocarriers can be designed as DDSs to overcome many of these drawbacks. One of the most versatile building blocks to prepare these nanocarriers is the ubiquitous, readily available and inexpensive protein, serum albumin. Areas covered: This review covers the use of different types of albumin (human, bovine, rat, and chicken egg) to prepare... 

    Fatigue fracture of friction-stir processed Al-Al3Ti-MgO hybrid nanocomposites

    , Article International Journal of Fatigue ; Volume 87 , 2016 , Pages 266-278 ; 01421123 (ISSN) Sahandi Zangabad, P ; Khodabakhshi, F ; Simchi, A ; Kokabi, A. H ; Sharif University of Technology
    Elsevier Ltd  2016
    Abstract
    This paper presents experimental results on the fatigue properties of Al-matrix nanocomposites prepared by the friction stir processing (FSP) technique. An Al-Mg alloy (AA5052) with different amounts (∼2 and 3.5 vol%) of pre-placed TiO2 nanoparticles were FSPed up to 6 passes to attain homogenous dispersion of nano-metric inclusions. Microstructural studies by electron microscopic and electron back scattering diffraction (EBSD) techniques showed that nano-metric Al3Ti (50 nm), TiO2 (30 nm), and MgO (50 nm) particles were distributed throughout a fine-grained Al matrix (<2 μm). Consequently, a significant improvement in the tensile strength and hardness was attained. Uniaxial... 

    Nanomedicine and advanced technologies for burns: Preventing infection and facilitating wound healing

    , Article Advanced Drug Delivery Reviews ; Volume 123 , 2018 , Pages 33-64 ; 0169409X (ISSN) Mofazzal Jahromi, M. A ; Sahandi Zangabad, P ; Moosavi Basri, S. M ; Sahandi Zangabad, K ; Ghamarypour, A ; Aref, A. R ; Karimi, M ; Hamblin, M. R ; Sharif University of Technology
    Elsevier B.V  2018
    Abstract
    According to the latest report from the World Health Organization, an estimated 265,000 deaths still occur every year as a direct result of burn injuries. A widespread range of these deaths induced by burn wound happens in low- and middle-income countries, where survivors face a lifetime of morbidity. Most of the deaths occur due to infections when a high percentage of the external regions of the body area is affected. Microbial nutrient availability, skin barrier disruption, and vascular supply destruction in burn injuries as well as systemic immunosuppression are important parameters that cause burns to be susceptible to infections. Topical antimicrobials and dressings are generally... 

    Friction-Stir Processed Al-Al3Ti-MgO Hybrid Nanocomposites

    , M.Sc. Thesis Sharif University of Technology Sahandi Zangabad, Parham (Author) ; Kokabi, Amir Hossein (Supervisor) ; Simchi, Abdolreza (Supervisor)
    Abstract
    In recent years, investigation of mechanical properties of micro- and nano-structure materials, and peculiarly nanocomposites have been attracted a wide variety of researches. In this regard, friction-stir-processed (FSPed) metal matrix nanocomposites have been considered an important case with appropriate mechanical properties especially for fabrication of ultra-fine grained Al alloys and Al-matrix nanocomposites. In this research, Al matrix hybrid nanocomposites were fabricated via multi passes-friction stir processing (FSP) of Al-Mg alloy (AA5052) with different amounts (~2 and 3 vol%) of pre-placed TiO2 (30 nm) particles nanoparticles. It was revealed that employing of cumulative FSP up... 

    Plant protein-based hydrophobic fine and ultrafine carrier particles in drug delivery systems

    , Article Critical Reviews in Biotechnology ; Volume 38, Issue 1 , 2018 , Pages 47-67 ; 07388551 (ISSN) Malekzad, H ; Mirshekari, H ; Sahandi Zangabad, P ; Moosavi Basri, S. M ; Baniasadi, F ; Sharifi Aghdam, M ; Karimi, M ; Hamblin, M. R ; Sharif University of Technology
    Taylor and Francis Ltd  2018
    Abstract
    For thousands of years, plants and their products have been used as the mainstay of medicinal therapy. In recent years, besides attempts to isolate the active ingredients of medicinal plants, other new applications of plant products, such as their use to prepare drug delivery vehicles, have been discovered. Nanobiotechnology is a branch of pharmacology that can provide new approaches for drug delivery by the preparation of biocompatible carrier nanoparticles (NPs). In this article, we review recent studies with four important plant proteins that have been used as carriers for targeted delivery of drugs and genes. Zein is a water-insoluble protein from maize; Gliadin is a 70% alcohol-soluble... 

    PH-Sensitive stimulus-responsive nanocarriers for targeted delivery of therapeutic agents

    , Article Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology ; Volume 8, Issue 5 , 2016 , Pages 696-716 ; 19395116 (ISSN) Karimi, M ; Eslami, M ; Sahandi Zangabad, P ; Mirab, F ; Farajisafiloo, N ; Shafaei, Z ; Ghosh, D ; Bozorgomid, M ; Dashkhaneh, F ; Hamblin, M. R ; Sharif University of Technology
    Wiley-Blackwell  2016
    Abstract
    In recent years miscellaneous smart micro/nanosystems that respond to various exogenous/endogenous stimuli including temperature, magnetic/electric field, mechanical force, ultrasound/light irradiation, redox potentials, and biomolecule concentration have been developed for targeted delivery and release of encapsulated therapeutic agents such as drugs, genes, proteins, and metal ions specifically at their required site of action. Owing to physiological differences between malignant and normal cells, or between tumors and normal tissues, pH-sensitive nanosystems represent promising smart delivery vehicles for transport and delivery of anticancer agents. Furthermore, pH-sensitive systems... 

    Nanotechnology in diagnosis and treatment of coronary artery disease

    , Article Nanomedicine ; Volume 11, Issue 5 , 2016 , Pages 513-530 ; 17435889 (ISSN) Karimi, M ; Zare, H ; Bakhshian Nik, A ; Yazdani, N ; Hamrang, M ; Mohamed, E ; Sahandi Zangabad, P ; Moosavi Basri, S. M ; Bakhtiari, L ; Hamblin, M. R ; Sharif University of Technology
    Future Medicine Ltd  2016
    Abstract
    Nanotechnology could provide a new complementary approach to treat coronary artery disease (CAD) which is now one of the biggest killers in the Western world. The course of events, which leads to atherosclerosis and CAD, involves many biological factors and cellular disease processes which may be mitigated by therapeutic methods enhanced by nanotechnology. Nanoparticles can provide a variety of delivery systems for cargoes such as drugs and genes that can address many problems within the arteries. In order to improve the performance of current stents, nanotechnology provides different nanomaterial coatings, in addition to controlled-release nanocarriers, to prevent in-stent restenosis.... 

    Insights on the speed of sound in ionic liquid binary mixtures: Investigation of influential parameters and construction of predictive models

    , Article Journal of Molecular Liquids ; Volume 326 , 2021 ; 01677322 (ISSN) Sahandi, P. J ; Salimi, M ; Iranshahi, D ; Sharif University of Technology
    Elsevier B.V  2021
    Abstract
    Relative novelty and wide functionality of ionic liquids (ILs) have led to a surge in the studies devoted to experimental determination of their physicochemical properties. Systematic collection and analysis of the available data and development of predictive models to address the extreme diversity of IL systems are of great value in this regard. In the present work, the significance of speed of sound in ILs and their mixtures was outlined and related theoretical concepts were surveyed. A comprehensive database was utilized for the construction of predictive models based on least square support vector machine. By constructing four different models, the influence of temperature, molecular... 

    Applications of innovation technologies for personalized cancer medicine: stem cells and gene-editing tools

    , Article ACS Pharmacology and Translational Science ; Volume 6, Issue 12 , 2023 , Pages 1758-1779 ; 25759108 (ISSN) Hasanzadeh, A ; Ebadati, A ; Dastanpour, L ; Aref, A. R ; Sahandi Zangabad, P ; Kalbasi, A ; Dai, X ; Mehta, G ; Ghasemi, A ; Fatahi, Y ; Joshi, S ; Hamblin, M. R ; Karimi, M ; Sharif University of Technology
    American Chemical Society  2023
    Abstract
    Personalized medicine is a new approach toward safer and even cheaper treatments with minimal side effects and toxicity. Planning a therapy based on individual properties causes an effective result in a patient’s treatment, especially in a complex disease such as cancer. The benefits of personalized medicine include not only early diagnosis with high accuracy but also a more appropriate and effective therapeutic approach based on the unique clinical, genetic, and epigenetic features and biomarker profiles of a specific patient’s disease. In order to achieve personalized cancer therapy, understanding cancer biology plays an important role. One of the crucial applications of personalized... 

    Nanocaged platforms: Modification, drug delivery and nanotoxicity. Opening synthetic cages to release the tiger

    , Article Nanoscale ; Volume 9, Issue 4 , 2017 , Pages 1356-1392 ; 20403364 (ISSN) Sahandi Zangabad, P ; Karimi, M ; Mehdizadeh, F ; Malekzad, H ; Ghasemi, A ; Bahrami, S ; Zare, H ; Moghoofei, M ; Hekmatmanesh, A ; Hamblin, M. R ; Sharif University of Technology
    Royal Society of Chemistry  2017
    Abstract
    Nanocages (NCs) have emerged as a new class of drug-carriers, with a wide range of possibilities in multi-modality medical treatments and theranostics. Nanocages can overcome such limitations as high toxicity caused by anti-cancer chemotherapy or by the nanocarrier itself, due to their unique characteristics. These properties consist of: (1) a high loading-capacity (spacious interior); (2) a porous structure (analogous to openings between the bars of the cage); (3) enabling smart release (a key to unlock the cage); and (4) a low likelihood of unfavorable immune responses (the outside of the cage is safe). In this review, we cover different classes of NC structures such as virus-like... 

    Stimulus-responsive liposomes as smart nanoplatforms for drug delivery applications

    , Article Nanotechnology Reviews ; 2017 ; 21919089 (ISSN) Sahandi Zangabad, P ; Mirkiani, S ; Shahsavari, S ; Masoudi, B ; Masroor, M ; Hamed, H ; Jafari, Z ; Davatgaran Taghipour, Y ; Hashemi, H ; Karimi, M ; Hamblin, M. R ; Sharif University of Technology
    2017
    Abstract
    Liposomes are known to be promising nanoparticles (NPs) for drug delivery applications. Among different types of self-assembled NPs, liposomes stand out for their non-toxic nature, and their possession of dual hydrophilic-hydrophobic domains. Advantages of liposomes include the ability to solubilize hydrophobic drugs, the ability to incorporate different hydrophilic and lipophilic drugs at the same time, lessening the exposure of host organs to potentially toxic drugs and allowing modification of the surface by a variety of different chemical groups. This modification of the surface, or of the individual constituents, may be used to achieve two important goals. Firstly, ligands for active... 

    Stimulus-responsive liposomes as smart nanoplatforms for drug delivery applications

    , Article Nanotechnology Reviews ; Volume 7, Issue 1 , 2018 , Pages 95-122 ; 21919089 (ISSN) Sahandi Zangabad, P ; Mirkiani, S ; Shahsavari, S ; Masoudi, B ; Masroor, M ; Hamed, H ; Jafari, Z ; Davatgaran Taghipour, Y ; Hashemi, H ; Karimi, M ; Hamblin, M. R ; Sharif University of Technology
    Walter de Gruyter GmbH  2018
    Abstract
    Liposomes are known to be promising nanoparticles (NPs) for drug delivery applications. Among the different types of self-assembled NPs, liposomes stand out for their non-toxic nature and their possession of dual hydrophilic-hydrophobic domains. The advantages of liposomes include the ability to solubilize hydrophobic drugs, the ability to incorporate different hydrophilic and lipophilic drugs at the same time, lessening the exposure of host organs to potentially toxic drugs and allowing modification of the surface by a variety of different chemical groups. This modification of the surface, or of the individual constituents, may be used to achieve two important goals. First, ligands for... 

    Poly-L-lysine/hyaluronan nanocarriers as a novel nanosystem for gene delivery

    , Article Journal of Microscopy ; Volume 287, Issue 1 , 2022 , Pages 32-44 ; 00222720 (ISSN) Souri, M ; Bagherzadeh, M. A ; Mofazzal Jahromi, M. A ; Mohammad-Beigi, H ; Abdoli, A ; Mir, H ; Roustazadeh, A ; Pirestani, M ; Sahandi Zangabad, P ; Kiani, J ; Bakhshayesh, A ; Jahani, M ; Joghataei, M. T ; Karimi, M ; Sharif University of Technology
    John Wiley and Sons Inc  2022
    Abstract
    The present research comes up with a novel DNA-loaded poly-L-lysine (PLL)/hyaluronan (HA) nanocarrier (DNA-loaded PLL/HA NCs) for gene delivery applications, as a promising candidate for gene delivery into diverse cells. A straightforward approach was employed to prepare such a nanosystem through masking DNA-loaded PLL molecules by HA. Fourier-transform infrared (FTIR) spectroscopy, dynamic light scattering (DLS), field emission-scanning electron microscopy (FE-SEM) and transmission electron microscopy (TEM) were used to analyse the interaction of the molecules as well as the physicochemical properties of the NCs. The NCs showed a negative charge of –24 ± 3 mV, with an average size of 138 ±... 

    Noble metal nanoparticles in biosensors: Recent studies and applications

    , Article Nanotechnology Reviews ; Volume 6, Issue 3 , 2017 , Pages 301-329 ; 21919089 (ISSN) Malekzad, H ; Sahandi Zangabad, P ; Mirshekari, H ; Karimi, M ; Hamblin, M. R ; Sharif University of Technology
    Walter de Gruyter GmbH  2017
    Abstract
    The aim of this review is to cover advances in noble metal nanoparticle (MNP)-based biosensors and to outline the principles and main functions of MNPs in different classes of biosensors according to the transduction methods employed. The important biorecognition elements are enzymes, antibodies, aptamers, DNA sequences, and whole cells. The main readouts are electrochemical (amperometric and voltametric), optical (surface plasmon resonance, colorimetric, chemiluminescence, photoelectrochemical, etc.) and piezoelectric. MNPs have received attention for applications in biosensing due to their fascinating properties. These properties include a large surface area that enhances biorecognizers... 

    Smart micro/nanoparticles in stimulus-responsive drug/gene delivery systems

    , Article Chemical Society Reviews ; Volume 45, Issue 5 , 2016 , Pages 1457-1501 ; 03060012 (ISSN) Karimi, M ; Ghasemi, A ; Sahandi Zangabad, P ; Rahighi, R ; Moosavi Basri, S. M ; Mirshekari, H ; Amiri, M ; Shafaei Pishabad, Z ; Aslani, A ; Bozorgomid, M ; Ghosh, D ; Beyzavi, A ; Vaseghi, A ; Aref, A. R ; Haghani, L ; Bahrami, S ; Hamblin, M. R ; Sharif University of Technology
    Royal Society of Chemistry  2016
    Abstract
    New achievements in the realm of nanoscience and innovative techniques of nanomedicine have moved micro/nanoparticles (MNPs) to the point of becoming actually useful for practical applications in the near future. Various differences between the extracellular and intracellular environments of cancerous and normal cells and the particular characteristics of tumors such as physicochemical properties, neovasculature, elasticity, surface electrical charge, and pH have motivated the design and fabrication of inventive "smart" MNPs for stimulus-responsive controlled drug release. These novel MNPs can be tailored to be responsive to pH variations, redox potential, enzymatic activation, thermal... 

    Smart nanostructures for cargo delivery: uncaging and activating by light

    , Article Journal of the American Chemical Society ; Volume 139, Issue 13 , 2017 , Pages 4584-4610 ; 00027863 (ISSN) Karimi, M ; Sahandi Zangabad, P ; Baghaee Ravari, S ; Ghazadeh, M ; Mirshekari, H ; Hamblin, M. R ; Sharif University of Technology
    2017
    Abstract
    Nanotechnology has begun to play a remarkable role in various fields of science and technology. In biomedical applications, nanoparticles have opened new horizons, especially for biosensing, targeted delivery of therapeutics, and so forth. Among drug delivery systems (DDSs), smart nanocarriers that respond to specific stimuli in their environment represent a growing field. Nanoplatforms that can be activated by an external application of light can be used for a wide variety of photoactivated therapies, especially light-triggered DDSs, relying on photoisomerization, photo-cross-linking/un-cross-linking, photoreduction, and so forth. In addition, light activation has potential in photodynamic... 

    Simulation of continuous catalytic conversion of glycerol into lactic acid in a microreactor system: A CFD study

    , Article Journal of Industrial and Engineering Chemistry ; Volume 104 , 2021 , Pages 258-271 ; 1226086X (ISSN) Jalal Sahandi, P ; Kazemeini, M ; Sadjadi, S ; Sharif University of Technology
    Korean Society of Industrial Engineering Chemistry  2021
    Abstract
    Hand in hand with the flourish of the biodiesel industry, glycerol (GLY) as an inconvenient by-product has generated environmental and sustainability concerns. Devising measures for efficient transformation of GLY into value-added products is a promising solution. In this contribution, the transformation of GLY to lactic acid (LA) as a valuable chemical was investigated in a continuous process for industrial applications. In this regard, a catalytic method using heterogeneous Cu nanoparticles in NaOH solution was studied in a microreactor by a CFD simulation. A seven-inlet micromixer comprising an optimized mixing unit was incorporated for uniform distribution of the species. The effects of... 

    Production of Lactic Acid from Glycerol in Microchannel Reactors in the Presence of Copper-Based Catalysts

    , M.Sc. Thesis Sharif University of Technology Jalal Sahandi, Pooya (Author) ; Kazemeini, Mohammad (Supervisor) ; Sadjadi, Samaheh (Supervisor)
    Abstract
    Hand in hand with the flourish of the biodiesel industries, glycerol has turned into an abundant waste chemical posing obstacles to their large-scale implementation. Devising measures for efficient transformation of glycerol into value added products is a promising alternative to its large-scale disposal into the nature that would also increase the competitiveness of biodiesel fuels. In this study, production of lactic acid (LA) as a valuable chemical with wide applicability is studied in a continuous process with glycerol as a cheap and convenient feedstock. In this regard, the state-of-the-art approaches in catalytic conversion of glycerol to LA are reviewed. A catalytic method using... 

    Noble metal nanostructures in optical biosensors: basics, and their introduction to anti-doping detection

    , Article TrAC - Trends in Analytical Chemistry ; Volume 100 , 2018 , Pages 116-135 ; 01659936 (ISSN) Malekzad, H ; Sahandi Zangabad, P ; Mohammadi, H ; Sadroddini, M ; Jafari, Z ; Mahlooji, N ; Abbaspour, S ; Gholami, S ; Ghanbarpoor, M ; Pashazadeh, R ; Beyzavi, A ; Karimi, M ; Hamblin, M. R ; Sharif University of Technology
    Elsevier B.V  2018
    Abstract
    Nanotechnology has illustrated significant potentials in biomolecular-sensing applications; particularly its introduction to anti-doping detection is of great importance. Illicit recreational drugs, substances that can be potentially abused, and drugs with dosage limitations according to the prohibited lists announced by the World Antidoping Agency (WADA) are becoming of increasing interest to forensic chemists. In this review, the theoretical principles of optical biosensors based on noble metal nanoparticles, and the transduction mechanism of commonly-applied plasmonic biosensors are covered. We review different classes of recently-developed plasmonic biosensors for analytic determination...