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    Dosimetric evaluation of a newly developed radiochromic film for radiation processing

    , Article Iranian Journal of Science and Technology, Transaction A: Science ; Volume 31, Issue 4 , 2007 , Pages 397-401 ; 10286276 (ISSN) Akhavan, A ; Sohrabpour, M ; Sharifzadeh, M ; Sharif University of Technology
    Shiraz University  2007
    In order to improve the performance of a newly developed radiochromic film, GIC-79, some dosimetric characteristics of this film have been studied based on relevant standard practice. The present study describes some parameters that may affect the dosimeter response before, during, and after irradiation. The effect of absorbed dose rate on dosimeter response was determined by irradiating dosimeters at low absorbed dose rates with gamma rays. Calibration irradiations of dosimeters were performed with both gamma rays and also electrons to determine the effect of large difference absorbed dose rates on dosimeter response. In addition, post irradiation stability was obtained and also the... 

    Integrated and inherently safe design and operation of a mobile power generation: Process intensification through microreactor reformer and HT-PEMFC

    , Article International Journal of Hydrogen Energy ; Volume 46, Issue 46 , 2021 , Pages 23839-23854 ; 03603199 (ISSN) Ghodba, A ; Sharifzadeh, M ; Rashtchian, D ; Sharif University of Technology
    Elsevier Ltd  2021
    In the present study, due to various advantages of process miniaturization, the integrated design and operation of a mobile power generation system consisting of a microreactor reformer and a proton exchange membrane fuel cell (PEMFC) are investigated. The hydrogen fuel is supplied through autothermal steam-reforming of methanol in a microreactor leading to a safer, as well as more efficient, and economical operation. A high-temperature polymer membrane fuel cell with external accessories is applied for power generation. Then, simulation-optimization programming is applied for simultaneously optimizing the process design and operation at the same level. The result shows that the implemented... 

    Inherently safe and economically optimal design using multi-objective optimization: The case of a refrigeration cycle

    , Article Process Safety and Environmental Protection ; Volume 104 , 2016 , Pages 254-267 ; 09575820 (ISSN) Eini, S ; Shahhosseini, H. R ; Javidi, M ; Sharifzadeh, M ; Rashtchian, D ; Sharif University of Technology
    Institution of Chemical Engineers  2016
    The economic viability of industrial processes strongly depends on their safe and reliable operation. The method of inherent safe process design enables systematic consideration of safety measures in order to ensure process safe operation at the early stages of process design. The challenge is that the economic measures that are often considered for the design of industrial processes are often incommensurable with the safety measures. In the present research, a novel framework is proposed in which the safety criteria are quantified based on consequence modeling and aggregated with the economic performance using multi-objective optimization programming. The developed methodology was applied... 

    Developing group contribution models for the estimation of Atmospheric Lifetime and Minimum Ignition Energy

    , Article Chemical Engineering Science ; Volume 226 , 2020 Eini, S ; Jhamb, S ; Sharifzadeh, M ; Rashtchian, D ; Kontogeorgis, G. M ; Sharif University of Technology
    Elsevier Ltd  2020
    The Atmospheric Lifetime (ALT) of a compound represents the potential for the atmospheric accumulation of chemicals. Chemicals with a long lifetime are more resistant to natural decomposition and remain in the environment for a longer period. Minimum Ignition Energy (MIE) is one of the most important properties when evaluating hazardous chemicals. Despite the significance of these environment and safety-related properties, currently, there are no group contribution (GC) models that enable their predictive modeling. The present research aims at filling this gap. To this end, experimental data were collected from literature and the GC model parameters were estimated using the weighted... 

    Design of peptide-based inhibitor agent against amyloid-β aggregation: Molecular docking, synthesis and in vitro evaluation

    , Article Bioorganic Chemistry ; Volume 102 , September , 2020 Jokar, S ; Erfani, M ; Bavi, O ; Khazaei, S ; Sharifzadeh, M ; Hajiramezanali, M ; Beiki, D ; Shamloo, A ; Sharif University of Technology
    Academic Press Inc  2020
    Formation of the amyloid beta (Aβ) peptide aggregations represents an indispensable role in appearing and progression of Alzheimer disease. β-sheet breaker peptides can be designed and modified with different amino acids in order to improve biological properties and binding affinity to the amyloid beta peptide. In the present study, three peptide sequences were designed based on the hopeful results of LIAIMA peptide and molecular docking studies were carried out onto the monomer and fibril structure of amyloid beta peptide using AutoDock Vina software. According to the obtained interactions and binding energy from docking, the best-designed peptide (D-GABA-FPLIAIMA) was chosen and...