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torkashvand--rezvan
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A Quantitative Structure-Activity Relationship Study on Multiple Sclerosis (MS) Drugs
, M.Sc. Thesis Sharif University of Technology ; Jalali-Heravi, Mehdi (Supervisor)
Abstract
In the present work we report a quantitative structure-activity relationship (QSAR) study on S1P1 receptor’s agonists that have therapeutic potential for autoimmune disorders such as Multiple Sclerosis (MS). Such studies play an important role in drug design and lead optimization by developing a mathematical relationship between the chemical structures of compounds and their biological activities.
We used both linear and nonlinear techniques such as MLR and ANN respectively to model these compounds together with techniques such as Stepwise-MLR, GA-MLR and GA-ANN in the variable selection step as it is an important step in every QSAR study. Since topological descriptors are well...
We used both linear and nonlinear techniques such as MLR and ANN respectively to model these compounds together with techniques such as Stepwise-MLR, GA-MLR and GA-ANN in the variable selection step as it is an important step in every QSAR study. Since topological descriptors are well...
Effect of Major Principal Stress Direction Rotation on Cyclic Behavior of Dense Sand Using Dynamic Hollow Cylinder Aparratus
, M.Sc. Thesis Sharif University of Technology ; Jafarzadeh, Fardin (Supervisor)
Abstract
In the past years a lot of research has been done on effects of different parameters on dynamic behavior of soils. According to these studies, principal stress direction rotation and intermediate principal stress coefficient have a major effect on monotonic behavior of soils, but more studies needed for observingtheir effect on dynamic behavior of soils.
In recent study undrained isotropic consolidated specimens of dense Babolsar sand subjected to α changes using dynamic hollow cylinder apparatus and the inner and outer cell pressure kept constant so that b was relative to α changes.
Fisrt series of testswere done to find an appropriate value for induced cyclic deviator stress. The...
In recent study undrained isotropic consolidated specimens of dense Babolsar sand subjected to α changes using dynamic hollow cylinder apparatus and the inner and outer cell pressure kept constant so that b was relative to α changes.
Fisrt series of testswere done to find an appropriate value for induced cyclic deviator stress. The...
Curcumin incorporated PVA-borax dual delivery hydrogels as potential wound dressing materials—Correlation between viscoelastic properties and curcumin release rate
, Article Journal of Applied Polymer Science ; Volume 135, Issue 45 , 2018 ; 00218995 (ISSN) ; Pircheraghi, G ; Bagheri, R ; Sharif University of Technology
John Wiley and Sons Inc
2018
Abstract
Poly(vinyl alcohol) (PVA) is a biocompatible polymer which can be physically crosslinked by Borax to form hydrogel. PVA-Borax (PB) hydrogel is a promising candidate for drug delivery system. Therefore, it is necessary to find the quantitative relationship between drug release rate and network structure of PB hydrogels to predict and control drug release rate. In this work, at first step the optimum ratio of Borax: PVA was determined by studying the interactions between PVA chains and Borax molecules by means of Fourier transform infrared spectroscopy, while viscoelastic properties of prepared PB hydrogels were measured in the oscillatory shear flow field. In the following, curcumin as a...
Applications of Statistical Learning in Dynamic Pricing
, M.Sc. Thesis Sharif University of Technology ; Haji Mir Sadeghi, Mir Omid (Supervisor)
Abstract
In the era of the internet and with the emergence of online stores, the possibility of changing prices for these e-commerce platforms has become simple and virtually cost-free. This allows them to adjust prices optimally in response to environmental and surrounding factors, maximizing their revenue from product sales. This development has led to numerous applications of statistical learning methods, particularly online learning, in these markets. In this thesis, we explore the issue of online pricing from various perspectives. One aspect is that product pricing is based on their features, which can be numerous. This leads us to the use of online learning methods and statistical learning in...
Tailoring Software Testing Techiques for Product Line Engineering
, M.Sc. Thesis Sharif University of Technology ; Mirian-Hosseinabadi, Hassan (Supervisor)
Abstract
In industry it is usual to develop a family of similar software instead of a single one. Software product-line (SPL) engineering or family-based software engineering is an approach that tries to minimize needed effort and time-to-market and maximize quality of manufactured products through strategic planning for maximizing reuse among members of the family. On the other hand it is known that testing software is an indivisible part of software development process which requires considerable time and effort. With large number of products created from an SPL, it is obvious that testing should be conducted in such a way that needed effort does not maintain a linear relationship with number of...
The Study on Relationship between Viscoelastic Properties and Drug Release of Wound Dress Polyvinyl Alcohol Hydrogel
, M.Sc. Thesis Sharif University of Technology ; Bagheri, Reza (Supervisor) ; Pircheraghi, Gholamreza (Supervisor)
Abstract
Wound is a defect or failure in the skin texture which occurs as a result of physical or heat injuries or physiological conditions. The wound dress as a temporary cover can improve wound healing process and due to the unique properties, hydrogels have become appropriate choice for this application. Hydrogel’s structure allows drug to be loaded in the wound dress. Hydrogel wound dress should have adequate fluidity to cover wound’s bed and make full contact with the skin. Sufficient cohesion and strength is also necessary to allow the wound dress to remove from wound completely. Therefore, the study on the viscoelastic properties of hydrogel is important. In this study, polyvinyl alcohol...
Parametric Investigation on Microstructure and Mechanical Properties of Ultrasonic Spot welded Aluminium and Copper Sheets
, M.Sc. Thesis Sharif University of Technology ; Kokabi, Amir Hossain (Supervisor) ; Abedini, Rezvan (Co-Supervisor)
Abstract
Ultrasonic metal welding is a solid state welding process and is widely used in welding the connections of lithium-ion battery batteries in hybrid and plug-in hybrid vehicles. This welding process has advantages over fusion welding processes such as; Shorter time, no heat affected area, optimal energy consumption, cheaper equipment and no harm to the environment. The aim of this study was to investigate the effect and optimization of time, normal pressure and oscillation amplitude parameters in order to achieve the maximum tensile-shear test force and T-peel test in the dissimilar welding of 1050 aluminum and copper (purity above 99.9%). In order to achieve the optimal state of welding...
Design and Implementation of an Intelligent UVC Disinfection Robot based on IoT Technology
, Article 7th International Conference on Internet of Things and Applications, IoT 2023 ; 2023 ; 979-835036941-0 (ISBN) ; Naderian, S ; Roshanaei, M ; Ashrafs, M. G ; Kiani, S ; Torkashvand, M ; Sharif University of Technology
Institute of Electrical and Electronics Engineers Inc
2023
Abstract
In this paper, an intelligent UV disinfection robot based on Internet of Things (IoT) technology is proposed. The proposed method is used to reduce human operator roles and risks with the help of IoT based monitoring of the robot. The intelligent disinfection robot consists of two important parts. The first one is the mobile robot which is controlled remotely and wirelessly based on Raspberry Pi 3 Model B+ as a wireless microcontroller. Furthermore, Passive Infrared (PIR) and Ultrasonic sensors are installed on the mobile robot to detect human presence and obstacles, respectively. The second one is a tower unit that contains four ultraviolet-type C (UVC) lamps and a Raspberry Pi camera. The...
Designed amino acid feed in improvement of production and quality targets of a therapeutic monoclonal antibody
, Article PLoS ONE ; Volume 10, Issue 10 , October , 2015 ; 19326203 (ISSN) ; Vaziri, B ; Maleknia, S ; Heydari, A ; Vossoughi, M ; Davami, F ; Mahboudi, F ; Sharif University of Technology
Public Library of Science
2015
Abstract
Cell culture feeds optimization is a critical step in process development of pharmaceutical recombinant protein production. Amino acids are the basic supplements of mammalian cell culture feeds with known effect on their growth promotion and productivity. In this study, we reported the implementation of the Plackett-Burman (PB) multifactorial design to screen the effects of amino acids on the growth promotion and productivity of a Chinese hamster ovary DG-44 (CHO-DG44) cell line producing bevacizumab. After this screening, the amino acid combinations were optimized by the response surface methodology (RSM) to determine the most effective concentration in feeds. Through this strategy, the...
Quantitative proteomic analysis of cellular responses to a designed amino acid feed in a monoclonal antibody producing Chinese hamster ovary cell line
, Article Iranian Biomedical Journal ; Volume 22, Issue 6 , 2018 , Pages 385-393 ; 1028852X (ISSN) ; Mahboudi, F ; Vossoughi, M ; Fatemi, E ; Moosavi Basri, S. M ; Heydari, A ; Vaziri, B ; Sharif University of Technology
Pasteur Institute of Iran
2018
Abstract
Background: Chinese hamster ovary (CHO) cell line is considered as the most common cell line in the biopharmaceutical industry because of its capability in performing efficient post-translational modifications and producing the recombinant proteins, which are similar to natural human proteins. The optimization of the upstream process via different feed strategies has a great impact on the target molecule expression and yield. Methods: To determine and understand the molecular events beneath the feed effects on the CHO cell, a label-free quantitative proteomic analysis was applied. The proteome changes followed by the addition of a designed amino acid feed to the monoclonal antibody producing...
Investigation of Operating Parameters for Thorium Adsorption from Wastewater by Using of Radiated Grafting Polymeric Adsorbents in Packed Bed Column
, M.Sc. Thesis Sharif University of Technology ; Outokesh, Mohamad (Supervisor) ; Torab Mostaedi, Meysam (Supervisor) ; Asadollahzadeh, Mehdi (Co-Supervisor) ; Torkaman, Rezvan (Co-Supervisor)
Abstract
Today, the pollution of heavy metals in wastewater and surface waters, which is a global environmental problem, has increased with the expansion of various industrial activities. Heavy metals cause serious health problems due to their accumulation in human and animal tissues. Thorium, is a radioactive element with an atomic number of 90 that is widely used in the optics, aerospace, metallurgy and chemical industries, in the manufacture of high-strength alloys, in UV photocells, and especially in the nuclear industry. The primary sources of radioactive wastewater include nuclear power plants, nuclear energy industry research centers, medical institutions, industrial production, universities,...
Synthesis and Characterization of Polymer Nanofibers Modified by Using of Radiated Grafting for Adsorption of Molybdenum Ions from Aqueous Solution
, M.Sc. Thesis Sharif University of Technology ; Outokesh, Mohammad (Supervisor) ; Asadollahzadeh, Mehdi (Supervisor) ; Torkaman, Rezvan (Co-Supervisor) ; Torab Mostaedi, Meysam (Co-Supervisor)
Abstract
Molybdenum is one of the important elements of the intermediary metal with atomic number 42, which is used in various industries, but among the important uses of this metal in the nuclear industry, we can mention the presence of this element in the production of yellow cake as an impurity and also as a precursor for the production of radiopharmaceuticals. It is one of the impurities that remain in all stages of yellow cake production along with uranium, and the high presence of this element causes the centrifuges to become unbalanced during the injection of "U" "F" _"6" gas, and on the other hand, technetium, the main ingredient in the production of radiopharmaceuticals, It comes from the...