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vosughi--manouchehr
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Drug Delivery in Cardiovascular System with Multi Scale Approach
, M.Sc. Thesis Sharif University of Technology ; Vosughi, Manouchehr (Supervisor) ; Saeedi, Mohammad Saeed (Supervisor) ; Firoozabadi, Bahar (Supervisor)
Abstract
Particle retention and clearance is a major concern in the treatment of pulmonary diseases. Inhaled materials into the nasal and lung airways include gases/vapors, liquid droplets and soluble/insoluble particulate matter which can be toxic or therapeutic (or both). For example, nanoparticles (NPs), as part of nanomedicine, are now being used as drug carriers for passive and active targeting of solid tumors and inflamed tissue. However, natural and especially manmade NPs can also be harmful, such as carbon nanotubes (CNTs), asbestos fibers and ambient toxic pollutants, based on epidemiological and pathological studies of occupational and environmental exposures. In fact, ultrafine particles...
Experimental Study and Prediction of Vancomycin Partitioningin Surfactant-Salt Aqueous Two-Phase Systems
, M.Sc. Thesis Sharif University of Technology ; Vosughi, Manouchehr (Supervisor) ; Rashtchian, Davood (Supervisor) ; Pazuki, Gholamreza (Supervisor)
Abstract
In the past years, upstream processes have been receiving a considerable R&D investment and commercial attention. The downstream processes have, however, been overlooked causing a production bottleneck that is shifting the costs of production from up to downstream. The need to develop more efficient and cost-effective separation and purification processes is, thus, crucial in order to improve process efficiency and economics keeping the required high standards of quality for market approval. In this research, promising aqueous two-phase systems (ATPS) containing Tween 20 as a quite biocompatible non-ionic surfactant and different salts (K3Citrate and NaH2PO4) were prepared and their...