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Catalyst-Free and Green Synthesis of Some Novel Benzamide Derivatives
, Article Journal of Heterocyclic Chemistry ; Volume 52, Issue 6 , November , 2015 , Pages 1848-1857 ; 0022152X (ISSN) ; Rostami, M ; Mirkhani, V ; Moghadam, M ; Mohammadpoor Baltork, I ; Tangestaninejad, S ; Jamali Moghadam, A ; Kia, R ; Sharif University of Technology
HeteroCorporation
2015
Abstract
In the present work, a simple, green, rapid, and catalyst-free procedure for the synthesis of benzamide derivatives by ring opening of azlactones with diamines such as ethylene diamine and 1,3-propylenediamine is described. The present method offers several advantages such as short reaction times, easy work-up, and mild reaction conditions in the absence of catalyst and any toxic solvent and material. In addition, the structure obtained by X-ray crystallography was compared with the theoretical results obtained by density functional theory using the B3LYP functional and cc-pVDZ basis sets