Search for: acetonitrile-derivative
0.005 seconds

    Stereoelectronic effects: A simple yet powerful tool to manipulate anion affinity

    , Article Organic and Biomolecular Chemistry ; Volume 13, Issue 7 , Dec , 2015 , Pages 2170-2176 ; 14770520 (ISSN) Samet, M ; Fattahi, A ; Kass, S.R ; Sharif University of Technology
    Royal Society of Chemistry  2015
    Different strategies are employed in designing strong and selective anion receptors but stereoelectronic effects have been largely ignored. In this work, the stereo configuration of a non-interacting ether is found to have a large impact of more than two orders of magnitude on the binding of a rigid diol with tetrabutylammonium chloride in acetonitrile-d3. A favorable carbon-oxygen dipole and an intramolecular C-H⋯OH hydrogen bond in an equatorially substituted ether is found to be energetically more important than a stabilizing hydrogen bond in the corresponding axially oriented alcohol. IR spectroscopy is also used to probe the structures of the bound complexes and several binding motifs... 

    Separation of phenolic glycolipids in mycobacterium bovis BCG by reversed-phase high performance liquid chromatography

    , Article Pakistan Journal of Pharmaceutical Sciences ; Volume 22, Issue 2 , 2009 , Pages 145-149 ; 1011601X (ISSN) Salimi, M ; Pourabdi, L ; Zakeri, M ; Abdipour, N ; Sharif University of Technology
    A crude phenolic glycolipid extract from Mycobacterium bovis BCG was fractionated by column chromatography. A reversed-phase high performance liquid chromatography (HPLC) method with UV detection at 275nm was developed for simultaneous detection and separation of phenolic glycolipids (PGLs) in Mycobacterium bovis BCG. This analysis provides a good resolution. Different solvent systems and columns for HPLC were compared. A system composed of acetonitrile-water in the ratio of 0→80% at a flow rate of 0.8 mL/min and C8 analytical column were found to be optimum for HPLC of the phenolic glycolipids. This simple method is therefore appropriate to purify these compounds present in M. bovis extract...