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Modeling of Oxygen Transport and Exchange in an Acinus
, M.Sc. Thesis Sharif University of Technology ; Saeedi, Mohammad Saeed (Supervisor)
Abstract
An acinus is defined as the complex of airways supplied by one first order respiratory or transitional bronchiole. In this part, the replenishment of oxygen at the alveolar surface occurs by a combination of convective air flow with diffusion of oxygen in the air. So for studying gas exchange in the lung, modeling gas species transport and exchange in an acinus is important. Due to lacking direct measurements of the distribution of oxygen (or carbon dioxide) concentration in the acinus, several mathematical models have been developed and studied by numerical simulations. But in none of them the influence of breathing pattern and the role of blood flow in restricting the gas exchange rate have...
Numerical Investigation of Nano-Particles Dispersion and Deposition in Curved and Bifurcating Channels using Lattice Boltzmann Method
, M.Sc. Thesis Sharif University of Technology ; Moosavi, Ali (Supervisor)
Abstract
Investigation of transport and deposition of aerosol particles attracts interests in many fields of sciences. Various numerical and computational methods has been utilized in particulate flows studies. In recent relevant researches lattice Boltzmann method has been widely used and is reported to be a robust and efficient method. In present study, numerical investigation of dispersion and deposition of aerosol particles is performed in curved and bifurcating channels using LBM. Fluid flow simulations are performed using LBM while one-way coupling Lagrangian point of view is used for particle tracking. As the first showcase, transport and deposition of aerosol particles in channel flow with...
Air Flow and Respiratory Gas Exchange Simulation in Acinar Region of Human Lung
, M.Sc. Thesis Sharif University of Technology ; Saeedi, Mohammad Saeed (Supervisor)
Abstract
The main function of respiratory system is to exchange gasses between air and blood. However selection of the suitable geometry and solution of the fluid flow precede all other phenomena in the lung, including particle deposition and gas exchange. The most complicated phenomena take place at the terminal generations of the lung which is known as acinar region. Due to small dimensions and inability to use experimental measurements, numerical simulations are adequate methods in this region. In the first part of this thesis a method is proposed to reduce the computational space and make it possible to model all acinar region, simultaneously. Results show that the characteristic of streamlines...