Loading...
Search for: actin-polymerization
0.006 seconds

    Theoretical modeling of actin-retrograde-flow passing clusters of confined T cell receptors

    , Article Mathematical Biosciences ; Volume 283 , 2017 , Pages 1-6 ; 00255564 (ISSN) Ghasemi V., A ; Firoozabadi, B ; Saidi, M. S ; Sharif University of Technology
    Elsevier Inc  2017
    Abstract
    Through the activation process of T cells, actin filaments move from the cell periphery toward the cell center. The moving filaments engage with T cell receptors and thus contribute to transportation of the signaling molecules. To study the connection between the moving actin filaments and T cell receptors, an experiment available in the literature has measured filaments flow velocity passing over a region of confined clusters of receptors. It shows that flow velocity decreases in the proximity of the receptors, and then regains its normal value after traversing the region, suggesting a dissipative friction-like connection. In this work, we develop a minimal theoretical model to re-examine...