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    Controlled manipulation of a bio-particle using trolling mode atomic force microscope: a simulation study

    , Article Journal of Nanoparticle Research ; Volume 23, Issue 10 , 2021 ; 13880764 (ISSN) Mohammadi, S. Z ; Pishkenari, H. N ; Moghaddam, M. M ; Sajjadi, M ; Sharif University of Technology
    Springer Science and Business Media B.V  2021
    In the present study, a novel strategy based on particle motion mode is introduced to control the manipulation process of a bio-particle using trolling mode atomic force microscope. To achieve this goal, the reduced governing partial differential equations and the standard form of the system are used as a model for the system dynamic behavior. The governing equations take 6 degrees of freedom into account including extension, torsion, and two lateral bendings of the microcantilever as well as two lateral bendings of the nanoneedle. Manipulation process of the 500 nm radius particle on the substrate includes two phases named sticking and sliding. Sticking of the particle to the substrate... 

    Margination and adhesion of micro- and nanoparticles in the coronary circulation: A step towards optimised drug carrier design

    , Article Biomechanics and Modeling in Mechanobiology ; Volume 17, Issue 1 , 2018 , Pages 205-221 ; 16177959 (ISSN) Forouzandehmehr, M ; Shamloo, A ; Sharif University of Technology
    Springer Verlag  2018
    Obstruction of left anterior descending artery (LAD) due to the thrombosis or atherosclerotic plaques is the leading cause of death worldwide. Targeted delivery of drugs through micro- and nanoparticles is a very promising approach for developing new strategies in clot-busting or treating restenosis. In this work, we modelled the blood flow characteristics in a patient-specific reconstructed LAD artery by the fluid–solid interaction method and based on physiological boundary conditions. Next, we provided a Lagrangian description of micro- and nanoparticles dynamics in the blood flow considering their Brownian motion and the particle–particle interactions. Our results state that the number of...