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Imprinting Technology in Tumor Marker Detection
, M.Sc. Thesis Sharif University of Technology ; Abdekhodaie, Mohammad Jafar (Supervisor)
Abstract
Tumor markers are substances that are naturally found in blood and other fluids in body, but in abnormal conditions such as cancer and metastasis, their level increase. The aim of researching about tumor markers is to find a way for discovering cancer only with a blood test and replace with the current methods such as ELISA, and any type of cancer can be detected by these tests. In this study, molecular imprinted polymers were synthesized with biomolecules. To do that, silica microparticles were used as solid base and after functionalizing their surface, a thin film of polymer was synthesized on them. To optimize the components concentrations and the polymer thickness on the silica surface,...
Synthesis of Graphene Oxide Coating with Hydrophilic Polymers as Paclitaxel Anticancer Drug Delivery Systems
, M.Sc. Thesis Sharif University of Technology ; Adeli, Mohsen (Supervisor) ; Poujavadi, Ali (Co-Advisor)
Abstract
Nowadays, there is no perfect drug delivery for cancer therapy; also the healthy tissues can be damaged more than tumor tissues. To resolve this problem, the new drug delivery system based on nanostructured materials is useful. Graphene oxide (GO) is one of the most important graphene derivatives and a potential candidate for drug delivery system. It has high specific surface area so that it can load and deliver the drug in a good manner. Hydrophobicity of graphene restricts its application in nanomedicine. In order to improve its solubility in water, graphene should be modified by hydrophilic polymers. Therefore, in this study, in order to activate the graphene surface and increase its...