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    DNA Classification Using Optical Processing based on Alignment-free Methods

    , M.Sc. Thesis Sharif University of Technology Kalhor, Reza (Author) ; Koohi, Somayyeh (Supervisor)
    Abstract
    In this research, an optical processing method for DNA classification is presented in order to overcome the problems in the previous methods. With improving in the operational capacity of the sequencing process, which has increased the number of genomes, comparing sequences with a complete database of genomes is a serious challenge to computational methods. Most current classification programs suffer from either slow classification speeds, large memory requirements, or both. To achieve high speed and accuracy at the same time, we suggest using optical processing methods. The performance of electronic processing-based computing, especially in the case of large data processing, is usually... 

    Biological Sequences Comparison Based on Optical Processing

    , Ph.D. Dissertation Sharif University of Technology Akbari Rokn Abadi, Saeedeh (Author) ; Koohi, Somayyeh (Supervisor)
    Abstract
    Biological sequences, such as DNA, RNA, and proteins, contain vital information and activities of living organisms. Any changes or mutations in these sequences can alter the structure of proteins, which are the basis of all cell activities. This can cause disruptions in cellular functions. With advancements in cell data extraction technology, the amount of genetic data has increased, leading to a need for efficient methods to identify and study mutations. One of the primary tools for this work is biological sequence comparators. Despite the different types of sequence comparators available, there is still a need for an algorithm that is fast, accurate, scalable, and uses few resources....