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    Classification of asthma based on nonlinear analysis of breathing pattern

    , Article PLoS ONE ; Volume 11, Issue 1 , 2016 ; 19326203 (ISSN) Raoufy, M. R ; Ghafari, T ; Darooei, R ; Nazari, M ; Mahdaviani, S. A ; Eslaminejad, A. R ; Almasnia, M ; Gharibzadeh, S ; Mani, A. R ; Hajizadeh, S ; Sharif University of Technology
    Public Library of Science  2016
    Abstract
    Normal human breathing exhibits complex variability in both respiratory rhythm and volume. Analyzing such nonlinear fluctuations may provide clinically relevant information in patients with complex illnesses such as asthma. We compared the cycle-by-cycle fluctuations of inter-breath interval (IBI) and lung volume (LV) among healthy volunteers and patients with various types of asthma. Continuous respiratory datasets were collected from forty agematched men including 10 healthy volunteers, 10 patients with controlled atopic asthma, 10 patients with uncontrolled atopic asthma, and 10 patients with uncontrolled non-atopic asthma during 60 min spontaneous breathing. Complexity of breathing...