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Artificial neural network assisted kinetic spectrophotometric technique for simultaneous determination of paracetamol and p-aminophenol in pharmaceutical samples using localized surface plasmon resonance band of silver nanoparticles
, Article Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy ; Volume 138 , March , 2015 , Pages 474-480 ; 13861425 (ISSN) ; Dadfarnia, S ; Haji Shabani, A. M ; Rohani Moghadam, M ; Hormozi Nezhad, M. R ; Sharif University of Technology
Elsevier
2015
Abstract
Spectrophotometric analysis method based on the combination of the principal component analysis (PCA) with the feed-forward neural network (FFNN) and the radial basis function network (RBFN) was proposed for the simultaneous determination of paracetamol (PAC) and p-aminophenol (PAP). This technique relies on the difference between the kinetic rates of the reactions between analytes and silver nitrate as the oxidizing agent in the presence of polyvinylpyrrolidone (PVP) which is the stabilizer. The reactions are monitored at the analytical wavelength of 420 nm of the localized surface plasmon resonance (LSPR) band of the formed silver nanoparticles (Ag-NPs). Under the optimized conditions, the...