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Design of experiment, preparation, and in vitro biological assessment of human amniotic membrane extract loaded nanoparticles
, Article Current Pharmaceutical Biotechnology ; Volume 21, Issue 3 , 2020 , Pages 256-267 ; Atyabi, F ; Khoshayand, M. R ; Mahbod, R ; Cohan, R. A ; Akbarzadeh, I ; Bakhshandeh, H ; Sharif University of Technology
Bentham Science Publishers
2020
Abstract
Background: Human amniotic membrane grafting could be potentially useful in ocular surface complications due to tissue similarity and the presence of factors that reduce inflammation, vascu-larization, and scarring. However, considerations like donor-derived infectious risk and the requirement of an invasive surgery limit the clinical application of such treatments. Moreover, the quick depletion of bioactive factors after grafting reduces the efficacy of treatments. Therefore, in the current study, the possibility of nano delivery of the bioactive factors extracted from the human amniotic membrane to the ocular surface was investigated. Materials and Methods: Nanoparticles were prepared...
3D Bioprinting of Amniotic Membrane-Based Nanocomposite for Tissue Engineering Applications: Evaluation of Rheological, Mechanical and Biological Properties
, Ph.D. Dissertation Sharif University of Technology ; Simchi, Abdolreza (Supervisor) ; Tamjid, Elnaz (Supervisor) ; Niknejad, Hassan (Co-Supervisor)
Abstract
3D bioprinting is an additive manufacturing method that facilitates the deposition of the desired cells and biomaterials at any pre-defined location. This technique also enables control over the internal structure and external dimensions of printed constructs. Among various biomaterials used as bioinks, the bioinks derived from decellularized extracellular matrixes (dECMs) have attracted significant attention due to their bioactivity and being a rich source of biochemical cues. Here in this study, the decellularized amnion membrane (dAM) has been selected as the main component of the bioink formulation because of its biocompatibility, low immunogenicity, antibacterial property, abundance,...
Interaction analysis of a pregnant female uterus and fetus in a vehicle passing a speed bump
, Article Journal of Biomechanics ; Volume 118 , March , 2021 ; 00219290 (ISSN) ; Ahmadian, M. T ; Mohammadi, H ; Sharif University of Technology
Elsevier Ltd
2021
Abstract
Pregnant vehicle occupants experience relatively large acceleration when the vehicle passes a speed-bump. In this paper, the effect of such sudden acceleration on a pregnant uterus is investigated. A biomechanical model representing the fundamental dynamic behaviors of a pregnant uterus has been developed. The model relates to the 32nd week of gestation when the fetus is in head-down, occipito-anterior position. Considering the drag and squeeze effects of the amniotic fluid, we derive a comprehensive differential equation that represents the interaction of the uterus and fetus. Solving the governing equation, we obtain the system response to different speed-bump excitations. Using the fetal...