Sharif Digital Repository

Carbon nanotubes are among promising components for a wide range of applications, due to their unique properties; Specifically, They are a new alternative and efficient tool for transporting and translocating therapeutic molecules since they can translocate easily into the cytoplasm or nucleus of a cell through its membrane without generating an immunogenic response and toxic effects. While pristine carbon nanotubes are insoluble in all solvents, the organic functionalisation of carbon nanotubes is the prerequisite for their solubility profiles and their manipulation into biological systems. For this purpose, in this study, we first report the Amide-functionalization of CNTs which a direct... 

Introduction: Carbon nanotubes (CNT) have recently been studied as novel and versatile drug and gene delivery vehicles. When CNT are suitably functionalized, they can interact with various cell types and are taken up by endocytosis.Areas covered: Anti-cancer drugs cisplatin and doxorubicin have been delivered by CNT, as well as methotrexate, taxol and gemcitabine. The delivery of the antifungal compound amphotericin B and the oral administration of erythropoietin have both been assisted using CNT. Frequently, targeting moieties such as folic acid, epidermal growth factor or various antibodies are attached to the CNT-drug nanovehicle. Different kinds of functionalization (e.g., polycations)... 

Introduction: In recent years, the use of cost-effective, multifunctional, environmentally friendly and simple prepared nanomaterials/nanoparticles have been emerged considerably. In this manner, different synthesizing methods were reported and optimized, but there is still lack of a comprehensive method with multifunctional properties. Materials and Methods: In this study, we aim to synthesis the copper oxide nanoparticles using Achillea millefolium leaf extracts for the first time. Catalytic activity was investigated by in situ azide alkyne cycloaddition click and also A3 coupling reaction, and optimized in terms of temperature, solvent, and time of the reaction. Furthermore, the...