Sharif Digital Repository

Subject-specific parameters influence spinal loads and the risk of back disorders but their relative effects are not well understood. The objective of this study is to investigate the effects of changes in age (35–60 years), sex (male, female), body height (BH: 150–190 cm) and body weight (BW: 50–120 kg) on spinal loads in a full-factorial simulation using a personalized (spine kinematics, geometry, musculature and passive properties) kinematics driven musculoskeletal trunk finite element model. Segmental weight distribution (magnitude and location along the trunk) was estimated by a novel technique to accurately represent obesity. Five symmetric sagittal loading conditions were considered,... 

Gait training is a critical rehabilitation procedure for patients suffering from walking problems. It, however, puts the therapist in high orthopedic risk since he should prevent the patient from possible falling. Body weight support system is a new technology helping such patients and the involved therapist by unloading a percent of the patient's weight. A new over-ground body weight support is introduced in this article. The system is composed of two main modules namely unloading and traction. The unloading module is capable of suspending an individual's weight up to 1000N dynamically. The whole system is attached to an overhead rail, moving over the head of the patient by the traction... 

To help walking, using assistive devices can be considered to reduce the loads caused by weight and to effectively decrease the propulsive forces. In this study, a mobility Saddle-Assistive Device (S-AD) supporting body weight while walking was evaluated on two healthy volunteers. This device is based on the support of body weight against gravity with the help of a saddle, which is not used in other passive mobility assistive devices. To prove the efficiency of this device, the experimental results obtained while walking with this device were compared with those related to walking without the assistive device. The results showed that this device could significantly reduce the forces and... 

This paper focuses on the biomechanical aspects of human load carrying in order to provide a physiological framework for designing the more anthropometric assistive systems. An 8degrees-of-freedom musculoskeletal model with twenty functional muscle groups in the lower extremity was developed to simulate the movement in sagittal plane. Inverse dynamics based optimization approach was employed to estimate the excitation level of the muscles. Activation patterns of the muscles illustrate the importance role of the soleus in supporting of the body during load carrying. Also power distribution analysis of the muscles reveals that the plantar flexors of the ankle, extensors of the knee and hip... 

We proposed a personalized bolus advisor for patients with type 1 diabetes (T1D). A bolus advisor is a decision support system that recommends insulin doses based on an open-loop model-based optimization. To construct the bolus advisor, the optimal open-loop control of blood glucose (BG) concentration in T1D patients was represented as a multi-objective optimization problem. The insulin types, doses, and times for each injection were provided by the bolus advisor based on a personalized model and an average daily diet, which should be re-tuned frequently in specific time intervals. The constructed personalized model for T1D patients incorporates effects of the patient's age and body weight.... 

Development of a subject-specific computational musculoskeletal trunk model (accounting for age, sex, body weight and body height), estimation of muscle forces and internal loads as well as subsequent validation by comparison with measured intradiscal pressure in various lifting tasks are novel, important and challenging. The objective of the present study is twofold. First, it aims to update and personalize the passive and active structures in an existing musculoskeletal kinematics-driven finite element model. The scaling scheme used an existing imaging database and biomechanical principles to adjust muscle geometries/cross-sectional-areas and passive joint geometry/properties in accordance... 

During pregnancy, traumas can threaten maternal and fetal health. Various trauma effects on a pregnant uterus are little investigated. In the present study, a finite element model of a uterus along with a fetus, placenta, amniotic fluid, and two most effective ligament sets is developed. This model allows numerical evaluation of various loading on a pregnant uterus. The model geometry is developed based on CT-scan data and validated using anthropometric data. Applying Ogden hyper-elastic theory, material properties of uterine wall and placenta are developed. After simulating the “rigid-bar” abdominal loading, the impact force and abdominal penetration are investigated. Findings are compared... 

Abstract The aim of this study was to determine the effects of Mg supplementation on anthropometric indices consisting of body weight, waist circumference (WC), BMI and body fat percentage. In this systematic review and dose-response meta-analysis, we searched PubMed, Cochrane Library, Scopus, Web of Science and Google Scholar from databases inception up to February 2020 for relevant randomised controlled trials. Quality of evidence was evaluated using the Cochrane Collaboration Tool. All the outcomes of this meta-analysis were pooled using the random effect model. Analysis of dose-response for Mg dosage was carried out using a fractional polynomial model. The systematic review and... 

Epidemiological studies are divided over the causative role of body weight (BW) in low back pain. Biomechanical modeling is a valuable approach to examine the effect of changes in BW on spinal loads and risk of back pain. Changes in BW have not been properly simulated by previous models as associated alterations in model inputs on the musculature and moment arm of gravity loads have been neglected. A detailed, multi-joint, scalable model of the thoracolumbar spine is used to study the effect of BW (varying at five levels, i.e., 51, 68, 85, 102, and 119kg) on the L5-S1 spinal loads during various static symmetric activities while scaling moment arms and physiological cross-sectional areas of... 

Background: Nonalcoholic fatty liver disease (NAFLD) is the most abundant chronic liver disorder, because racial and ethnic differences may influence prevalence and severity of NAFLD. Objectives: This metabolomic study was conducted to identify the metabolic biomarkers and determine the mechanism of progress of NAFLD in Iranian patients. Methods: Serum samples were collected from 75 participants (37 healthy controls and 38 patients with NAFLD) after an overnight fast. The metabolome of all samples were determined by nuclear magnetic resonance (NMR) and were compared by multivariate statistical analysis. Results: Totally, 19 metabolomic biomarkers were identified by NMR. Compared to healthy... 

Excessive loads on the human spine is recognized as a risk factor for back injuries/pain. Various lifting analysis tools such as musculoskeletal models, regression equations and NIOSH (National Institute for Occupational Safety and Health) lifting equation (NLE) have been proposed to evaluate and mitigate associated risks during manual material handling activities. Present study aims to compare predicted spinal loads from 5 different lifting analysis tools as well as to critically evaluate the NIOSH recommended weight limit (RWL). Spinal loads were estimated under different symmetric/asymmetric lifting tasks in which hand-load mass at each task was set based on RWL from NLE. Estimated...