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anti-cancer-chemotherapy
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Nanocaged platforms: Modification, drug delivery and nanotoxicity. Opening synthetic cages to release the tiger
, Article Nanoscale ; Volume 9, Issue 4 , 2017 , Pages 1356-1392 ; 20403364 (ISSN) ; Karimi, M ; Mehdizadeh, F ; Malekzad, H ; Ghasemi, A ; Bahrami, S ; Zare, H ; Moghoofei, M ; Hekmatmanesh, A ; Hamblin, M. R ; Sharif University of Technology
Royal Society of Chemistry
2017
Abstract
Nanocages (NCs) have emerged as a new class of drug-carriers, with a wide range of possibilities in multi-modality medical treatments and theranostics. Nanocages can overcome such limitations as high toxicity caused by anti-cancer chemotherapy or by the nanocarrier itself, due to their unique characteristics. These properties consist of: (1) a high loading-capacity (spacious interior); (2) a porous structure (analogous to openings between the bars of the cage); (3) enabling smart release (a key to unlock the cage); and (4) a low likelihood of unfavorable immune responses (the outside of the cage is safe). In this review, we cover different classes of NC structures such as virus-like...
Doxorubicin-loaded graphene oxide nanocomposites in cancer medicine: stimuli-responsive carriers, co-delivery and suppressing resistance
, Article Expert Opinion on Drug Delivery ; Volume 19, Issue 4 , 2022 , Pages 355-382 ; 17425247 (ISSN) ; Saebfar, H ; Gholami, M.H ; Hushmandi, K ; Zabolian, A ; Bikarannejad, P ; Hashemi, M ; Daneshi, S ; Mirzaei, S ; Sharifi, E ; Kumar, A.P ; Khan, H ; Heydari Sheikh Hossein, H ; Vosough, M ; Rabiee, N ; Kumar Thakur, V ; Makvandi, P ; Mishra, Y. K ; Tay, F. R ; Wang, Y ; Zarrabi, A ; Orive, G ; Mostafavi, E ; Sharif University of Technology
Taylor and Francis Ltd
2022
Abstract
Introduction: The application of doxorubicin (DOX) in cancer therapy has been limited due to its drug resistance and poor internalization. Graphene oxide (GO) nanostructures have the capacity for DOX delivery while promoting its cytotoxicity in cancer. Areas covered: The favorable characteristics of GO nanocomposites, preparation method, and application in cancer therapy are described. Then, DOX resistance in cancer, GO-mediated photothermal therapy, and DOX delivery for cancer suppression are described. Preparation of stimuli-responsive GO nanocomposites, surface functionalization, hybrid nanoparticles, and theranostic applications are emphasized in DOX chemotherapy. Expert opinion: GO...