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Temperature-responsive smart nanocarriers for delivery of therapeutic agents: applications and recent advances
, Article ACS Applied Materials and Interfaces ; Volume 8, Issue 33 , 2016 , Pages 21107-21133 ; 19448244 (ISSN) ; Sahandi Zangabad, P ; Ghasemi, A ; Amiri, M ; Bahrami, M ; Malekzad, H ; Ghahramanzadeh Asl, H ; Mahdieh, Z ; Bozorgomid, M ; Ghasemi, A ; Rahmani Taji Boyuk, M. R ; Hamblin, M. R ; Sharif University of Technology
American Chemical Society
2016
Abstract
Smart drug delivery systems (DDSs) have attracted the attention of many scientists, as carriers that can be stimulated by changes in environmental parameters such as temperature, pH, light, electromagnetic fields, mechanical forces, etc. These smart nanocarriers can release their cargo on demand when their target is reached and the stimulus is applied. Using the techniques of nanotechnology, these nanocarriers can be tailored to be target-specific, and exhibit delayed or controlled release of drugs. Temperature-responsive nanocarriers are one of most important groups of smart nanoparticles (NPs) that have been investigated during the past decades. Temperature can either act as an external...