Loading...
Search for: antiinfective-agent
0.006 seconds
Total 41 records

    Highly efficient hydroxyapatite/TiO2 composites covered by silver halides as E. coli disinfectant under visible light and dark media

    , Article Photochemical and Photobiological Sciences ; Volume 12, Issue 10 , October , 2013 , Pages 1787-1794 Azimzadehirani, M ; Elahifard, M ; Haghighi, S ; Gholami, M. R. (Mohammad Reza) ; Sharif University of Technology
    Abstract
    TiO2-based photocatalysts are seen as the most common agents for the photodegradation of bacteria. In this study, AgCl/TiO2, hydroxyapatite(Hp)/AgCl/TiO2, AgI/TiO2, and Hp/AgI/TiO2 were prepared by the deposition-precipitation method on P25 TiO2 nanoparticles and were characterized by XRD, SEM, FT-IR, EDX and BET methods. The prepared composites showed high efficiency for the inactivation of Escherichia coli (E. coli) bacteria under visible light and in dark media with different catalyst amounts of 12 and 24 mg, respectively. In less than 30 min, AgI/TiO2, prepared by the combination of cationic surfactant and PVPI2, disinfected 1 × 10(7) colony-forming units of E. coli completely. However,... 

    Synergistic Wound Healing by Novel Ag@ZIF-8 Nanostructures

    , Article International Journal of Pharmaceutics ; Volume 629 , 2022 ; 03785173 (ISSN) Barjasteh, M ; Mohsen Dehnavi, S ; Ahmadi Seyedkhani, S ; Yahya Rahnamaee, S ; Golizadeh, M ; Sharif University of Technology
    Elsevier B.V  2022
    Abstract
    In this paper, novel zeolitic imidazolate framework-8 (ZIF-8) functionalized with Ag (Ag@ZIF-8) nanoparticles were synthesized through a green, facile and environmental-friendly process for wound dressing applications. X-ray diffraction revealed that the ZIF-8 and Ag@ZIF-8 were successfully synthesized by green solvents at ambient temperature. Field-emission scanning electron microscopy indicated a homogeneous porous blend of ∼30 nm chitosan/bacterial cellulose (CS/BC) nanofibers embedded with ∼80–110 nm nanoparticles of the ZIF-8 and Ag@ZIF-8. Transmission electron microscopy revealed the Ag@ZIF-8 nanostructures consist of ZIF-8 cores that are covered by 5–20 nm Ag nanoparticles. MTT assay... 

    Selective fluorometric determination of sulfadiazine based on the growth of silver nanoparticles on graphene quantum dots

    , Article Microchimica Acta ; Volume 187, Issue 1 , 2020 Afsharipour, R ; Haji Shabani, A. M ; Dadfarnia, S ; Kazemi, E ; Sharif University of Technology
    Springer  2020
    Abstract
    A sensitive fluorometric assay is described for the direct determination of the antibiotic sulfadiazine. Silver nanoparticles placed on graphene quantum dots (Ag NP-GQDs) were synthesized by reduction of AgNO3 with sodium borohydride in the presence of GQDs. The growth of Ag NPs on the surface of the GQDs causes quenching of the blue fluorescence of the GQDs with an emission maximum at 470 nm by surface-enhanced energy transfer. If sulfadiazine is added, it interacts with Ag NPs and fluorescence is restored. Under optimal conditions, the fluorescence increases linearly in the sulfadiazine concentration range of 0.04–22.0 μM. The detection limit is 10 nM with relative standard deviations of... 

    Antibacterial and antifungal activity of methanolic extracts of Salix alba L. against various disease causing pathogens

    , Article Brazilian journal of biology = Revista brasleira de biologia ; Volume 83 , 2021 , Pages e243332- ; 16784375 (ISSN) Javed, B ; Farooq, F ; Ibrahim, M ; Abbas, H. A. B ; Jawwad, H ; Zehra, S. S ; Ahmad, H. M ; Sarwer, A ; Malik, K ; Nawaz, K ; Sharif University of Technology
    NLM (Medline)  2021
    Abstract
    The present study was aimed to manifest the antibacterial and antifungal activity of methanolic extracts of Salix alba L. against seven Gram-positive and Gram-negative bacterial pathogens e.g. Streptococcus pyogenes, Staphylococcus aureus (1), S. aureus (2), Shigella sonnei, Escherichia coli (1), E. coli (2) and Neisseria gonorrhoeae and three fungal isolates from the air such as Aspergillus terreus, A. ornatus, and Rhizopus stolonifer. Two different serotypes of S. aureus and E. coli were used. The agar well-diffusion method results showed the dose-dependent response of plant extracts against bacterial and fungal strains while some organisms were found resistant e.g. E. coli (1), S. sonnei,... 

    MIL-125-based nanocarrier decorated with Palladium complex for targeted drug delivery

    , Article Scientific Reports ; Volume 12, Issue 1 , 2022 ; 20452322 (ISSN) Bagherzadeh, M ; Safarkhani, M ; Kiani, M ; Radmanesh, F ; Daneshgar, H ; Ghadiri, A. M ; Taghavimandi, F ; Fatahi, Y ; Safari-Alighiarloo, N ; Ahmadi, S ; Rabiee, N ; Sharif University of Technology
    Nature Research  2022
    Abstract
    The aim of this work was to provide a novel approach to designing and synthesizing a nanocomposite with significant biocompatibility, biodegradability, and stability in biological microenvironments. Hence, the porous ultra-low-density materials, metal–organic frameworks (MOFs), have been considered and the MIL-125(Ti) has been chosen due to its distinctive characteristics such as great biocompatibility and good biodegradability immobilized on the surface of the reduced graphene oxide (rGO). Based on the results, the presence of transition metal complexes next to the drug not only can reinforce the stability of the drug on the structure by preparing π–π interaction between ligands and the... 

    Multifunctional green synthesized Cu–Al layered double hydroxide (LDH) nanoparticles: anti-cancer and antibacterial activities

    , Article Scientific Reports ; Volume 12, Issue 1 , 2022 ; 20452322 (ISSN) Kiani, M ; Bagherzadeh, M ; Ghadiri, A. M ; Makvandi, P ; Rabiee, N ; Sharif University of Technology
    Nature Research  2022
    Abstract
    Doxorubicin (DOX) is a potent anti-cancer agent and there have been attempts in developing nanostructures for its delivery to tumor cells. The nanoparticles promote cytotoxicity of DOX against tumor cells and in turn, they reduce adverse impacts on normal cells. The safety profile of nanostructures is an important topic and recently, the green synthesis of nanoparticles has obtained much attention for the preparation of biocompatible carriers. In the present study, we prepared layered double hydroxide (LDH) nanostructures for doxorubicin (DOX) delivery. The Cu–Al LDH nanoparticles were synthesized by combining Cu(NO3)2·3H2O and Al(NO3)3·9H2O, and then, autoclave at 110. The green... 

    Highly efficient hydroxyapatite/TiO2 composites covered by silver halides as E. coli disinfectant under visible light and dark media

    , Article Photochemical and Photobiological Sciences ; Volume 12, Issue 10 , 2013 , Pages 1787-1794 ; 1474905X (ISSN) Azimzadehirani, M ; Elahifard, M ; Haghighi, S ; Gholami, M ; Sharif University of Technology
    2013
    Abstract
    TiO2-based photocatalysts are seen as the most common agents for the photodegradation of bacteria. In this study, AgCl/TiO2, hydroxyapatite(Hp)/AgCl/TiO2, AgI/TiO2, and Hp/AgI/TiO2 were prepared by the deposition-precipitation method on P25 TiO2 nanoparticles and were characterized by XRD, SEM, FT-IR, EDX and BET methods. The prepared composites showed high efficiency for the inactivation of Escherichia coli (E. coli) bacteria under visible light and in dark media with different catalyst amounts of 12 and 24 mg, respectively. In less than 30 min, AgI/TiO2, prepared by the combination of cationic surfactant and PVPI2, disinfected 1 × 107 colony-forming units of E. coli completely. However,... 

    Composite of methyl polysiloxane and avocado biochar as adsorbent for removal of ciprofloxacin from waters

    , Article Environmental Science and Pollution Research ; Volume 29, Issue 49 , 2022 , Pages 74823-74840 ; 09441344 (ISSN) Teixeira, R. A ; Lima, E. C ; Benetti, A. D ; Thue, P. S ; Lima, D. R ; Sher, F ; dos Reis, G. S ; Rabiee, N ; Seliem, M. K ; Abatal, M ; Sharif University of Technology
    Springer Science and Business Media Deutschland GmbH  2022
    Abstract
    Two carbon composite materials were prepared by mixing avocado biochar and methyl polysiloxane (MK). Firstly, MK was dissolved in ethanol, and then the biochar was added at different times. In sample 1 (R1), the time of adding biochar was immediately after dissolving MK in ethanol, and in sample 2 (R2), after 48 h of MK dissolved in ethanol. The samples were characterized by nitrogen adsorption/desorption measurements obtaining specific surface areas (SBET) of 115 m2 g−1 (R1) and 580 m2 g−1 (R2). The adsorbents were further characterized using scanning electron microscopy, FTIR and Raman spectroscopy, adsorption of vapors of n-heptane and water, thermal analysis, Bohem titration, pHpzc, and... 

    Polysaccharide-based nanocomposites for biomedical applications: a critical review

    , Article Nanoscale Horizons ; Volume 7, Issue 10 , 2022 , Pages 1136-1160 ; 20556756 (ISSN) Shokrani, H ; Shokrani, A ; Sajadi, S. M ; Khodadadi Yazdi, M ; Seidi, F ; Jouyandeh, M ; Zarrintaj, P ; Kar, S ; Kim, S. J ; Kuang, T ; Rabiee, N ; Hejna, A ; Saeb, M. R ; Ramakrishna, S ; Sharif University of Technology
    Royal Society of Chemistry  2022
    Abstract
    Polysaccharides (PSA) have taken specific position among biomaterials for advanced applications in medicine. Nevertheless, poor mechanical properties are known as the main drawback of PSA, which highlights the need for PSA modification. Nanocomposites PSA (NPSA) are a class of biomaterials widely used as biomedical platforms, but despite their importance and worldwide use, they have not been reviewed. Herein, we critically reviewed the application of NPSA by categorizing them into generic and advanced application realms. First, the application of NPSA as drug and gene delivery systems, along with their role in the field as an antibacterial platform and hemostasis agent is discussed. Then,... 

    Miniaturized salting-out liquid-liquid extraction in a coupled-syringe system combined with HPLC-UV for extraction and determination of sulfanilamide

    , Article Talanta ; Vol. 121 , April , 2014 , pp. 199-204 ; ISSN: 00399140 Sereshti, H ; Khosraviani, M ; Sadegh Amini-Fazl, M ; Sharif University of Technology
    Abstract
    In salting-out liquid-liquid extraction (SALLE) technique, water-miscible organic solvents are used for extraction of polar analytes from saline solutions. In this study, for the first time, a coupled 1-mL syringes system was utilized to perform a miniaturized SALLE method. Sulfanilamide antibiotic was extracted and determined via the developed method followed by high performance liquid chromatography-ultraviolet detection (HPLC-UV). The extraction process was carried out by rapid shooting of acetonitrile as extraction solvent (syringe B) into saline aqueous sample solution (syringe A), and then the shooting was repeated several times at a rate of 1 cycle s-1. Thereby, an extremely large... 

    Evaluating the toxic effect of an antimicrobial agent on single bacterial cells with optical tweezers

    , Article Biomedical Optics Express ; Volume 6, Issue 1 , 2015 , Pages 112-117 ; 21567085 (ISSN) Samadi, A ; Zhang, C ; Chen, J ; Reihani, S. N. S ; Chen, Z ; Sharif University of Technology
    OSA - The Optical Society  2015
    Abstract
    We implement an optical tweezers technique to assess the effects of chemical agents on single bacterial cells. As a proof of principle, the viability of a trapped Escherichia coli bacterium is determined by monitoring its flagellar motility in the presence of varying concentrations of ethyl alcohol. We show that the “killing time” of the bacterium can be effectively identified from the correlation statistics of the positional time series recorded from the trap, while direct quantification from the time series or associated power spectra is intractable. Our results, which minimize the lethal effects of bacterial photodamage, are consistent with previous reports of ethanol toxicity that used... 

    Antibacterial activity of ultra-small copper oxide (II) nanoparticles synthesized by mechanochemical processing against S. aureus and E. coli

    , Article Materials Science and Engineering C ; Volume 105 , 2019 ; 09284931 (ISSN) Moniri Javadhesari, S ; Alipour, S ; Mohammadnejad, S ; Akbarpour, M. R ; Sharif University of Technology
    Elsevier Ltd  2019
    Abstract
    In this paper, ultra-small CuO nanoparticles (NPs) were synthesized through a mechanochemical method using two different Cu-containing precursors (i.e. CuSO4·5H2O and CuCl2·2H2O), and their structure and antibacterial activity were studied. From the microstructural studies, it was observed that CuO NPs have a spherical morphology and a narrow size distribution with 7 and 14 nm median particle sizes for CuCl2·2H2O and CuSO4.5H2O precursors, respectively. The CuCl2·2H2O derived nanoparticles showed more antibacterial activity than CuSO4.5H2O derived nanoparticles. The minimum inhibitory concentration (MIC) of the synthesized nanoparticles (derived from both precursors) against E. coli and... 

    Fabrication and characterization of scaffolds containing different amounts of allantoin for skin tissue engineering

    , Article Scientific Reports ; Volume 11, Issue 1 , 2021 ; 20452322 (ISSN) Dorri Nokoorani, Y ; Shamloo, A ; Bahadoran, M ; Moravvej, H ; Sharif University of Technology
    Nature Research  2021
    Abstract
    Using the skin tissue engineering approach is a way to help the body to recover its lost skin in cases that the spontaneous healing process is either impossible or inadequate, such as severe wounds or burns. In the present study, chitosan/gelatin-based scaffolds containing 0.25, 0.5, 0.75, and 1% allantoin were created to improve the wounds’ healing process. EDC and NHS were used to cross-link the samples, which were further freeze-dried. Different in-vitro methods were utilized to characterize the specimens, including SEM imaging, PBS absorption and degradation tests, mechanical experiments, allantoin release profile assessment, antibacterial assay, and cell viability and adhesion tests.... 

    Nanofibrillated chitosan coated highly ordered titania nanotubes array/graphene nanocomposite with improved biological characters

    , Article Carbohydrate Polymers ; Volume 254 , 2021 ; 01448617 (ISSN) Rahnamaee, S. Y ; Bagheri, R ; Heidarpour, H ; Vossoughi, M ; Golizadeh, M ; Samadikuchaksaraei, A ; Sharif University of Technology
    Elsevier Ltd  2021
    Abstract
    Designing multifunctional surfaces is key to develop advanced materials for orthopedic applications. In this study, we design a double-layer coating, assembled onto the completely regular titania nanotubes (cRTNT) array. Benefiting from the biological and topological characteristics of chitosan nanofibers (CH) and reduced graphene oxide (RGO) through a unique assembly, the designed material features promoted osteoblast cell viability, prolonged antibiotic release profile, as well as inhibited bacterial biofilm formation. The synergistic effect of RGO and CH on the biological performance of the surface is investigatSed. The unique morphology of the nanofibers leads to the partial coverage of... 

    Amoxicillin-loaded multilayer pullulan-based nanofibers maintain long-term antibacterial properties with tunable release profile for topical skin delivery applications

    , Article International Journal of Biological Macromolecules ; Volume 215 , 2022 , Pages 413-423 ; 01418130 (ISSN) Ajalloueian, F ; Asgari, S ; Guerra, P. R ; Chamorro, C. I ; Ilchenco, O ; Piqueras, S ; Fossum, M ; Boisen, A ; Sharif University of Technology
    Elsevier B.V  2022
    Abstract
    Unique physiochemical and biological properties of nanofibers along with the choice of a wide variety of materials for both fabrication and tunable release patterns make nanofibers an ideal option for drug delivery. Loading antibacterial agents into nanofibers has attracted great deal of attention. Whilst there are several studies focusing on applying new generations of antibacterial materials, antibiotics are still the gold standard in clinical applications. Therefore, we aimed at introducing antibiotic-loaded nanofiber substrates with potential for topical skin delivery applications, reduced consumption of antibiotics and increased storage time. We applied Amoxicillin (AMX) as a model drug... 

    Antibacterial silver nanoparticles in polyvinyl alcohol/sodium alginate blend produced by gamma irradiation

    , Article International Journal of Biological Macromolecules ; Volume 80 , 2015 , Pages 170-176 ; 01418130 (ISSN) Eghbalifam, N ; Frounchi, M ; Dadbin, S ; Sharif University of Technology
    Abstract
    Polyvinyl alcohol/sodium alginate/nano silver (PVA/SA/Ag) composite films were made by solution casting method. Gamma irradiation was used to synthesize silver nanoparticles in situ via reduction of silver nitrate without using harmful chemical agents for biomedical applications. UV-vis and XRD results demonstrated that spherical silver nanoparticles were produced even at low irradiation dose of 5. kGy. By increasing irradiation dose, more nanoparticles were synthesized while no PVA hydrogel was formed up to 15. kGy. Also the size of nanoparticles was reduced with increasing gamma dose evidenced by higher release rate of silver nanoparticles in lukewarm water and SEM images. Comparing SEM... 

    Advances in skin regeneration: application of electrospun scaffolds

    , Article Advanced Healthcare Materials ; Volume 4, Issue 8 , 2015 , Pages 1114-1133 ; 21922640 (ISSN) Norouzi, M ; Boroujeni, S. M ; Omidvarkordshouli, N ; Soleimani, M ; Sharif University of Technology
    Wiley-VCH Verlag  2015
    Abstract
    The paucity of cellular and molecular signals essential for normal wound healing makes severe dermatological ulcers stubborn to heal. The novel strategies of skin regenerative treatments are focused on the development of biologically responsive scaffolds accompanied by cells and multiple biomolecules resembling structural and biochemical cues of the natural extracellular matrix (ECM). Electrospun nanofibrous scaffolds provide similar architecture to the ECM leading to enhancement of cell adhesion, proliferation, migration and neo tissue formation. This Review surveys the application of biocompatible natural, synthetic and composite polymers to fabricate electrospun scaffolds as skin... 

    Toxicity of graphene and graphene oxide nanowalls against bacteria

    , Article ACS Nano ; Volume 4, Issue 10 , October , 2010 , Pages 5731-5736 ; 19360851 (ISSN) Akhavan, O ; Ghaderi, E ; Sharif University of Technology
    2010
    Abstract
    Bacterial toxicity of graphene nanosheets in the form of graphene nanowalls deposited on stainless steel substrates was investigated for both Gram-positive and Gram-negative models of bacteria. The graphene oxide nanowalls were obtained by electrophoretic deposition of Mg2+-graphene oxide nanosheets synthesized by a chemical exfoliation method. On the basis of measuring the efflux of cytoplasmic materials of the bacteria, it was found that the cell membrane damage of the bacteria caused by direct contact of the bacteria with the extremely sharp edges of the nanowalls was the effective mechanism in the bacterial inactivation. In this regard, the Gram-negative Escherichia coli bacteria with an... 

    Ternary composite of TiO2 nanotubes/Ti plates modified by g-C3N4 and SnO2 with enhanced photocatalytic activity for enhancing antibacterial and photocatalytic activity

    , Article Journal of Photochemistry and Photobiology B: Biology ; Volume 178 , 2018 , Pages 124-132 ; 10111344 (ISSN) Faraji, M ; Mohaghegh, N ; Abedini, A ; Sharif University of Technology
    Elsevier B.V  2018
    Abstract
    A series of g-C3N4-SnO2/TiO2 nanotubes/Ti plates were fabricated via simple dipping of TiO2 nanotubes/Ti in a solution containing SnCl2 and g-C3N4 nanosheets and finally annealing of the plates. Synthesized plates were characterized by various techniques. The SEM analysis revealed that the g-C3N4-SnO2 nanosheets with high physical stability have been successfully deposited onto the surface of TiO2 nanotubes/Ti plate. Photocatalytic activity was investigated using two probe chemical reactions: oxidative decomposition of acetic acid and oxidation of 2-propanol under irradiation. Antibacterial activities for Escherichia coli (E. coli) bacteria were also investigated in dark and under UV/Vis... 

    Antibacterial properties of nanoporous graphene oxide/cobalt metal organic framework

    , Article Materials Science and Engineering C ; Volume 104 , 2019 ; 09284931 (ISSN) Hatamie, S ; Ahadian, M. M ; Soufi Zomorod, M ; Torabi, S ; Babaie, A ; Hosseinzadeh, S ; Soleimani, M ; Hatami, N ; Wei, Z. H ; Sharif University of Technology
    Elsevier Ltd  2019
    Abstract
    Metal-organic framework (MOF) based graphene oxide (GO) recently merits of attention because of the relative correspondence of GO with metal ions and organic binding linkers. Furthermore, introducing the GO to the Co-MOF to make a new nanoporous hybrid have are improved the selectivity and stability of the Co-MOF. Here the graphene oxide/cobalt metal organic framework (GO/Co-MOF) was synthesized by a solvothermal process using cobalt salt and terephthalic acid and used for biocidal activity, against the growth of the Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus bacteria. X-ray diffraction, Fourier transform infrared spectroscopy and Raman spectroscopy were confirmed...