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antineoplastic-antibiotic
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Controlled release of doxorubicin from electrospun PEO/chitosan/graphene oxide nanocomposite nanofibrous scaffolds
, Article Materials Science and Engineering C ; Volume 48 , March , 2015 , Pages 384-390 ; 09284931 (ISSN) ; Aboutalebi Anaraki, N ; Irani, M ; Roshanfekr Rad, L ; Shamshiri, S ; Sharif University of Technology
Elsevier Ltd
2015
Abstract
Polyethylene oxide (PEO)/chitosan (CS)/graphene oxide (GO) electrospun nanofibrous scaffolds were successfully developed via electrospinning process for controlled release of doxorubicin (DOX). The SEM analysis of nanofibrous scaffolds with different contents of GO (0.1, 0.2, 0.5 and 0.7 wt.%) indicated that the minimum diameter of nanofibers was found to be 85 nm for PEO/CS/GO 0.5% nanofibers. The π-π stacking interaction between DOX and GO with fine pores of nanofibrous scaffolds exhibited higher drug loading (98%) and controlled release of the DOX loaded PEO/CS/GO nanofibers. The results of DOX release from nanofibrous scaffolds at pH 5.3 and 7.4 indicated strong pH dependence. The...
Synthesis and characterization of magnetic hybrid nanomaterials via RAFT polymerization: A pH sensitive drug delivery system
, Article Colloids and Surfaces B: Biointerfaces ; Volume 174 , 2019 , Pages 153-160 ; 09277765 (ISSN) ; Kohestanian, M ; Shirzad, M ; Sharif University of Technology
Elsevier B.V
2019
Abstract
Herein, a facile and versatile method for the synthesis of a novel magnetic nanocarrier via surface- initiated reversible addition-fragmentation chain transfer (RAFT) polymerization is introduced. At first, RAFT agent was successfully attached to the surface of Fe 3 O 4 nanoparticles and, then, poly (glycidyl methacrylate) (PGMA) chains were grown and anchored onto the surface of Fe 3 O 4 nanoparticles. At the end, hydrazine (Hy) groups were introduced to the PGMA chains via reaction between epoxy rings and hydrazine molecules. Doxorubicin (DOX) was covalently conjugated to the prepared nanocarrier (Fe 3 O 4 @PGMA@Hy) through a hydrazone linkage. The in vitro drug release of Fe 3 O 4...