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    Drug delivery performance of nanocarriers based on adhesion and interaction for abdominal aortic aneurysm treatment

    , Article International Journal of Pharmaceutics ; Volume 594 , 2021 ; 03785173 (ISSN) Ebrahimi, S ; Vatani, P ; Amani, A ; Shamloo, A ; Sharif University of Technology
    Elsevier B.V  2021
    Targeted drug delivery using nanocarriers (NCs) is one of the novel techniques that has recently been used to improve drug delivery to the Abdominal aortic aneurysm (AAA) disease. The purpose of this study is to evaluate the surface density of NCs (SDNC) adhered via ligand-receptor binding to the inner wall of AAA. For this purpose, fluid–structure interaction (FSI) analysis was first performed for the patient-specific and ideal AAA models. Then, by injecting NCs into the aortic artery, the values of SDNC adhered to and interacted with AAA wall were obtained. Two types of NCs, liposomes, and solid particles in four different diameters, were used to investigate the effect of the diameter and...