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Graphene aerogel nanoparticles for in-situ loading/pH sensitive releasing anticancer drugs
, Article Colloids and Surfaces B: Biointerfaces ; Volume 186 , 2020 ; Akhavan, O ; Raoufi, M ; Varshochian, R ; Hosseini Motlagh, N. S ; Atyabi, F ; Sharif University of Technology
Elsevier B.V
2020
Abstract
Free polymer graphene aerogel nanoparticles (GA NPs) were synthesized by using reduction/aggregation of graphene oxide (GO) sheets in the presence of vitamin C (as a biocompatible reductant agent) at a low temperature (40 °C), followed by an effective sonication. Synthesis of GA NPs in doxorubicin hydrochloride (DOX)-containing solution results in the simultaneous synthesis and drug loading with higher performance (than that of the separately synthesized and loaded samples). To investigate the mechanism of loading and the capability of GA NPs in the loading of other drug structures, two groups of ionized (DOX, Amikacin sulfate and, D-glucosamine hydrochloride) and non-ionized (Paclitaxel...