Search for: artery-stenosis
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    Effect of Stenotic Carotid Geometry on Flow and Stroke-risk

    , M.Sc. Thesis Sharif University of Technology Amirkhosravi, Mehrad (Author) ; Firoozabadi, Bahar (Supervisor) ; Saeedi, Saeed (Supervisor)
    Carotid bifurcation is one of the most important bifurcations in human body which has a lot of curvature in some people. The common carotid artery bifurcates into an internal carotid artery (ICA) and an external carotid artery (ECA). The incidence of stenosis in carotid bifurcation and in particular in the internal carotid artery is of special importance. In the United States of America by 2006, nearly 700000 strokes occur each year, with about 160000 deaths and 20 to 30% of strokes are caused by stenotic carotid that cost estimated at $160 billion. The purpose of this thesis is to investigate in hemodynamic factors of blood flow such as velocity variation, vortex patterns, shear stress and... 

    Simulation of NO Production Process from Endothelial Cells and its Effect on Coronary Artery Flow Field

    , M.Sc. Thesis Sharif University of Technology Shahriari, Amir Hossein (Author) ; Firoozabadi, Bahar (Supervisor)
    Endothelial derived nitric oxide (NO) and its role in regulating the physiological conditions of blood vessels is one of the favorite topics among researchers. The majority of previous studies have focused on nitric oxide transport in blood vessels, less attention has been paid to its vasodilative effects in blood vessels. The main aim of this study is to propose an integrated model to study the effects of endothelial-derived nitric oxide on hemodynamic conditions of blood vessels. Nitric oxide is produced by endothelial cells upon exposure to mechanical forces such as hemodynamic shear stress. The synthesized nitric oxide then diffuses into the neighboring vascular smooth cells, where it... 

    Design of the Coronary Stent Device to Improve Fluid Flow in Coagulated Vascular Regions

    , M.Sc. Thesis Sharif University of Technology Haghayegh Jahromi, Mohammad (Author) ; Shamloo, Amir (Supervisor)
    The application of computational fluid dynamics (CFD) has been growing rapidly in biomedical engineering. The altered hemodynamics inside the blood vessels plays a key role in the development of the arterial disease called atherosclerosis, which is the major cause of human death worldwide. Atherosclerosis is often treated with the stenting procedure to restore the normal blood flow. A stent is a tubular, flexible structure, usually made of metals, which is driven and expanded in the blocked arteries. The presence of non-biological device in the artery causes inflammation or re-growth of atherosclerotic lesions in the treated vessels. Several factors including the design of stents and type of... 

    Simulation of Blood Flow Subjected to Magnetic Field

    , M.Sc. Thesis Sharif University of Technology Aalizadeh, Farhad (Author) ; Moosavi, Ali (Supervisor) ; Shafie, Mohammad Behshad (Supervisor)
    Considering the fact that there is a blood flow inside the vessels it is possible that blood flow is always associated with fouling and this may decrease the blood flow when a blood vessel is injured, the cells of your blood bond together to form a blood clot. The blood clot helps you stop bleeding. Blood clots are made of a combination of blood cells, platelets (small sticky cells that speed up the clot-making process), and fibrin (protein that forms a thread-like mesh to trap cells). Doctors call this kind of blood clot a “thrombus.” We study the effects of different parameters on the deposition of Nanoparticles on the surface of a bump in the blood vessels by the magnetic field. The... 

    Fabrication of Thick Scaffold with Microfluidic Channels by Bioprinter

    , M.Sc. Thesis Sharif University of Technology Khalighi, Sadaf (Author) ; Saadatmand, Maryam (Supervisor)
    Cardiovascular diseases are among the leading causes of death worldwide. For instance, in 2015, almost 31% of the world’s mortality rate was due to these causes. One of these diseases is cardiac coronary vessels’ occlusion which leads to the insufficient blood supply to the heart tissue and cardiomyocytes death after Myocardial Infarction (MI). After MI, a hierarchy of events in the heart tissue changes heart muscle and forms cardiac fibrosis. This fibrotic tissue does not have the native one’s properties and function, so it will cause cardiac arrest and patient death. Therefore, it is obvious that vascular network plays a crucial role in the heart function. The importance of cardiac... 

    Numerical Investigation of Hypertension in Plaque Formation and Growth in Human Aorta

    , M.Sc. Thesis Sharif University of Technology Benvidi, Amir Abbas (Author) ; Firoozabadi, Bahar (Supervisor)
    Nowadays, cardiovascular diseases are among the most prevalent cause of death worldwide. Besides, atherosclerosis is a cardiovascular disease happening with the continuous narrowing of vessels, especially medium and large-sized arteries. Moreover, the human aorta is vulnerable to this phenomenon. Atherosclerosis happens when the excess LDL in the blood flow penetrates the arterial wall. Then, the LDL is oxidized, thereby recruiting monocytes as the response against oxidized LDL. After monocytes enter the arterial wall, they differentiate and become macrophages. Macrophages then transform into foam cells by ingesting the oxidized LDL. The fatty foam cells are eventually responsible for the... 

    High precision invasive FFR, low-cost invasive iFR, or non-invasive CFR?: optimum assessment of coronary artery stenosis based on the patient-specific computational models

    , Article International Journal for Numerical Methods in Biomedical Engineering ; Volume 36, Issue 10 , 2020 Tajeddini, F ; Nikmaneshi, M. R ; Firoozabadi, B ; Pakravan, H. A ; Ahmadi Tafti, S. H ; Afshin, H ; Sharif University of Technology
    Wiley-Blackwell  2020
    The objective of this paper is to apply computational fluid dynamic (CFD) as a complementary tool for clinical tests to not only predict the present and future status of left coronary artery stenosis but also to evaluate some clinical hypotheses. In order to assess the present status of the coronary artery stenosis severity, and thereby selecting the most appropriate type of treatment for each patient, fractional flow reserve (FFR), instantaneous wave free-ratio (iFR), and coronary flow reserve (CFR) are calculated. To examine FFR, iFR, and CFR results, the effect of geometric features of stenoses, including diameter reduction (%), lesion length (LL), and minimum lumen diameter (MLD), is... 

    Simulation of Competitive Flow in the Coronary Arteries Bypass

    , M.Sc. Thesis Sharif University of Technology Azimi Nejad, Milad (Author) ; Firoozabadi, Bahar (Supervisor)
    Atherosclerosis is one of the most important factors for mortality and morbidity in the world. Coronary artery bypass graft (CABG) is applied for treatment of this disease which in this surgery, the patient vessels, such as internal thoracic artery and saphenous vein, are harvested and grafted to the coronary arteries. The graft success and its performance in short and long-term are depended on the much factors e.g. the severity of stenosis in the coronary artery. It should be noted that the low level of stenosis in the coronary artery causes the creation of undesirable phenomenon of competitive flow in the grafts after the surgery which this phenomenon has been reported as a cause of graft...