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artificial-vessels
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Fabrication and Surface Engineering of Pu-Tio2 Nanocomposites with Improved Mechanical, Surface and Hemocompatibility Properties with Usability in Vascular Tissue Engineering
, Ph.D. Dissertation Sharif University of Technology ; Baghery, Reza (Supervisor) ; Pourjavadi, Ali (Supervisor) ; Ghanbari, Hossein (Supervisor)
Abstract
The main focus of this project is the fabrication of surface engineering scaffolds based on polyurethane and titanium dioxide. The research's aim is the creation of the synergistic properties of TiO2 and PU as a new strategy for engineering artificial autologous blood vessels. In the first section, PU-TiO2 nanocomposites were synthesized by co-insitu synthesis of nanoparticles and polymer. The nanocomposite films were prepared by solvent casting and thermally induced phase separation methods. Mechanical and biological properties of films were compared with pure PU film. In solvent casting method, the outcomes revealed that the rate of endothelialization of the nanocomposite scaffold after 7...
Designing and Manufacturing of an Electrospinning Machine and Prediction of Mechanical Responses of Artificial Blood Vessels Using Neural Networks and Finite Element Analysis
, M.Sc. Thesis Sharif University of Technology ; Nourani, Amir (Supervisor) ; Chizari, Mahmoud (Co-Supervisor)
Abstract
Cardiovascular disease is one of the most leading causes of death in the world and one of the common methods for treating such diseases is replacing damaged blood vessels with artificial ones. Electrospinning, which is a method of producing polymer fibers, is one of the best and common methods of producing synthetic vessels. The first goal in this study was to create a suitable structure for fiber production; therefore, first, an electrospinning device and environmental chamber were designed and built. Then, the effect of alternative and uniform flow on the diameter and structure of the fibers was investigated using 15% wt. Polycaprolactone solution. The results of this study showed that the...