Loading...
Search for:
attenuation-correction
0.009 seconds
Implementation of absolute quantification in small-animal SPECT imaging: Phantom and animal studies
, Article Journal of Applied Clinical Medical Physics ; Volume 18, Issue 4 , 2017 , Pages 215-223 ; 15269914 (ISSN) ; Vosoughi, N ; Tanha, K ; Assadi, M ; Ghafarian, P ; Rahmim, A ; Ay, M. R
John Wiley and Sons Ltd
2017
Abstract
Purpose: Presence of photon attenuation severely challenges quantitative accuracy in single-photon emission computed tomography (SPECT) imaging. Subsequently, various attenuation correction methods have been developed to compensate for this degradation. The present study aims to implement an attenuation correction method and then to evaluate quantification accuracy of attenuation correction in small-animal SPECT imaging. Methods: Images were reconstructed using an iterative reconstruction method based on the maximum-likelihood expectation maximization (MLEM) algorithm including resolution recovery. This was implemented in our designed dedicated small-animal SPECT (HiReSPECT) system. For...
Implementation of Quantitative Analysis Capability on SPECT Images of HiReSPECT System
, M.Sc. Thesis Sharif University of Technology ; Vossoughi, Nasser (Supervisor) ; Ay, Mohammad Reza (Supervisor)
Abstract
Small animal SPECT imaging systems have a broad application in developing new diagnostic or therapeutic radiopharmaceutical and biomedical researches. The main goal of this imaging method is to determine distribution tendency and amount of radio pharmaceutics in body. In this study we have developed a reconstruction technique along with photon attenuation correction so as to obtain a high quality image and the finding a relationship between image matrix and absorbed radioisotope in tissues in order to quantify SPECT images with acceptable error range. In this research we have used MLEM method for image reconstruction and the obtained images were evaluated from quantitative and qualitative...
Monte Carlo Modeling of a Gamma Camera for Sm-153 Imaging in Targeted Radiotherapy and Benchmarking with Measured Data
, M.Sc. Thesis Sharif University of Technology ; Sohrabpour, Mostafa (Supervisor) ; Shokrani, Parvaneh (Co-Advisor)
Abstract
Metastatic bone is one of the most common causes pain in cancer patients. Because of Sm-153 emits gamma and beta, Sm-153 have been used for both of the diagnosis and treatment of metastases; Also Tc-99m have been used for the detection of metastases. Dosimetric studies in targeted radiotherapy require an accurate quantification of activity existing in different organs of a patient, which can be estimated from scintigraphic images. Quantitative imaging is difficult to perform because of several physical phenomena, such as scatter and attenuation, which lead to errors in activity determination and nuclear medicine image degradation.
In this work, we must determine the optimal...
In this work, we must determine the optimal...