Search for: azathioprine
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    The effect of conventional immunosuppressive therapy on cytokine serum levels in pemphigus vulgaris patients

    , Article Iranian Journal of Allergy, Asthma and Immunology ; Vol. 13, issue. 3 , June , 2014 , p. 174-183 ; 17351502 Mortazavi, H ; Esmaili, N ; Khezri, S ; Khamesipour, A ; Farahani, I. V ; Daneshpazhooh, M ; Rezaei N ; Sharif University of Technology
    Pemphigus vulgaris is an autoimmune disease, in which the role of Th17 cytokines needs to be further explored. This study was performed to assess serum levels of three interleukins (IL) required for Th17 differentiation (IL-β, IL-6 and IL-23) and two specific Th17 cytokines (IL- 17 and IL-22) in a group of patients with pemphigus vulgaris, at baseline, 3 weeks and 6 months after of treatment. Correlations between anti-desmogleins and cytokines with disease severity as well as the influence of therapy on the above factors were assessed. Forty-three first-admitted pemphigus vulgaris patients with the active disease entered the study, but only 31 completed the study. Forty-five healthy... 

    Pemphigus vulgaris and infections: A retrospective study on 155 patients

    , Article Autoimmune Diseases ; Volume 2013 , 2013 ; 20900430 (ISSN) Esmaili, N ; Mortazavi, H ; Noormohammadpour, P ; Boreiri, M ; Soori, T ; Vasheghani Farahani, I ; Mohit, M ; Sharif University of Technology
    Background. Autoimmune process and immunosuppressive therapy of pemphigus vulgaris would predispose the patients to infections. Aim. We aimed to study the prevalence of infection and pathogenic agents in pemphigus vulgaris patients admitted to dermatology service. Material and methods. This retrospective study was conducted on 155 pemphigus vulgaris patients (68 males, 87 females) admitted to dermatology service between 2009 and 2011. In this study, the diagnosis of pemphigus vulgaris was confirmed by light microscopic and direct immunofluorescence findings. Data were collected through a questionnaire. Results. Of 155 pemphigus vulgaris patients, 33 had infection at admission and 9 acquired... 

    Glassy carbon electrodes modified with a film of nanodiamond-graphite/chitosan: Application to the highly sensitive electrochemical determination of Azathioprine

    , Article Electrochimica Acta ; Volume 55, Issue 11 , 2010 , Pages 3621-3627 ; 00134686 (ISSN) Shahrokhian, S ; Ghalkhani, M ; Sharif University of Technology
    A novel modified glassy carbon electrode with a film of nanodiamond-graphite/chitosan is constructed and used for the sensitive voltammetric determination of azathioprine (Aza). The surface morphology and thickness of the film modifier are characterized using atomic force microscopy. The electrochemical response characteristics of the electrode toward Aza are investigated by means of cyclic voltammetry. The modified electrode showed an efficient catalytic role for the electrochemical reduction of Aza, leading to a remarkable decrease in reduction overpotential and enhancement of the kinetics of the electrode reaction with a significant increase of peak current. The effects of experimental... 

    Voltammetric studies of Azathioprine on the surface of graphite electrode modified with graphene nanosheets decorated with Ag nanoparticles

    , Article Materials Science and Engineering C ; Volume 58 , 2016 , Pages 1098-1104 ; 09284931 (ISSN) Asadian, E ; Iraji Zad, A ; Shahrokhian, S ; Sharif University of Technology
    Elsevier Ltd 
    By using graphene nanosheets decorated with Ag nanoparticles (AgNPs-G) as an effective approach for the surface modification of pyrolytic graphite electrode (PGE), a sensing platform was fabricated for the sensitive voltammetric determination of Azathioprine (Aza). The prepared AgNPs-G nanosheets were characterized using transmission electron microscopy (TEM), X-ray diffraction (XRD), UV-vis and Raman spectroscopy techniques. The electrochemical behavior of Aza was investigated by means of cyclic voltammetry. Comparing to the bare PGE, a remarkable enhancement was observed in the response characteristics of Aza on the surface of the modified electrode (AgNPs-G/PGE) as well as a noticeable... 

    Electrochemical study of Azathioprine at thin carbon nanoparticle composite film electrode

    , Article Electrochemistry Communications ; Volume 11, Issue 7 , 2009 , Pages 1425-1428 ; 13882481 (ISSN) Shahrokhian, S ; Ghalkhani, M ; Sharif University of Technology
    Thin carbon nanoparticle/Nafion film (CNP/N), as a novel electrode material, is formed on the surface of the glassy carbon electrode in a simple solvent evaporation process. The electrochemical behavior of Azathioprine (Aza) at the CNP/N-modified electrode is investigated in detail by the means of cyclic voltammetry. During the electrochemical reduction of Aza, an irreversible cathodic peak is appeared. Cyclic voltammetric studies indicated that the reduction process has an irreversible and adsorption-like behavior. The observed reduction peak is attributed to a four-electron process referring to the reduction of nitro group to the corresponding hydroxylamine. The prepared electrode showed...